Detail Information for IndEnz0002011623
IED ID IndEnz0002011623
Enzyme Type ID protease011623
Protein Name KappaPI-actitoxin-Avd3c
KappaPI-AITX-Avd3c
Kalicludine-2
AsKC2
Gene Name
Organism Anemonia sulcata (Mediterranean snakelocks sea anemone)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Cnidaria Anthozoa (anthozoans) Hexacorallia Actiniaria (sea anemones) Actiniidae Anemonia Anemonia sulcata (Mediterranean snakelocks sea anemone)
Enzyme Sequence INKDCLLPMDVGRCRARHPRYYYNSSSRRCEKFIYGGCRGNANNFITKKECEKVCGVR
Enzyme Length 58
Uniprot Accession Number Q9TWF9
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Dual-function toxin that inhibits both the serine protease trypsin (Kd<30 nM) and voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=1100 nM). {ECO:0000269|PubMed:7559645}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (3); Domain (1); Site (1)
Keywords Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Nematocyst;Potassium channel impairing toxin;Protease inhibitor;Secreted;Serine protease inhibitor;Toxin;Voltage-gated potassium channel impairing toxin
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:7559645}. Nematocyst {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 6,778
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda