| IED ID | IndEnz0002011679 |
| Enzyme Type ID | protease011679 |
| Protein Name |
PMA1 stabilization in the Golgi protein 1 Cleaved into: PSG1-N'; PSG1-C' |
| Gene Name | PSG1 YKL077W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MRFHDSILIFFSLASLYQHVHGARQVVRPKEKMTTSEEVKPWLRTVYGSQKELVTPTVIAGVTFSEKPEETPNPLKPWVSLEHDGRPKTIKPEINKGRTKKGRPDYSTYFKTVSSHTYSYEELKAHNMGPNEVFVEEEYIDEDDTYVSLNPIVRCTPNLYFNKGLAKDIRSEPFCTPYENSRWKVDKTYFVTWYTRFFTDENSGKVADKVRVHLSYVKENPVEKGNYKRDIPATFFSSEWIDNDNGLMPVEVRDEWLQDQFDRRIVVSVQPIYISDEDFDPLQYGILLYITKGSKVFKPTKEQLALDDAGITNDQWYYVALSIPTVVVVFFVFMYFFLYVNGKNRDFTDVTRKALNKKRRVLGKFSEMKKFKNMKNHKYTELPSYKKTSKQN |
| Enzyme Length | 392 |
| Uniprot Accession Number | P36081 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: With EXP1, the specific cargo receptor protein for the plasma membrane ATPase PMA1, is involved in the transport and/or maturation of PMA1 (PubMed:28727280). EXP1 and PSG1 probably act sequentially to promote PMA1 sorting between the ER and the Golgi, with EXP1 promoting PMA1 export from the ER to the Golgi while PSG1 has a role in PMA1 maturation or quality control in the Golgi (PubMed:28727280). PSG1 might also couple PMA1 sorting and maturation in the early secretory pathway with the glycosylation machinery (Probable). {ECO:0000269|PubMed:28727280, ECO:0000305|PubMed:28727280}.; FUNCTION: PSG1 is cleaved by KEX2 in two stable peptides, PSG1-N' and PSG1-C', the former supporting a role in maturation quality control, the latter having a role in modulating vesicular trafficking. {ECO:0000269|PubMed:28727280}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (3); Glycosylation (31); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cytoplasmic vesicle;Glycoprotein;Golgi apparatus;Membrane;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [PSG1-N']: Golgi apparatus lumen {ECO:0000269|PubMed:28727280}.; SUBCELLULAR LOCATION: [PSG1-C']: Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:28727280}; Single-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | PTM: The precursor protein is cleaved into two polypeptide chains, PSG1-N' and PSG1-C'. The cleavage is performed in the Golgi apparatus by Ca(+)-dependent serine protease KEX2 between Arg-229 and Asp-230. {ECO:0000269|PubMed:17210951, ECO:0000269|PubMed:28727280}.; PTM: PSG1-N' is highly O-mannosylated. {ECO:0000269|PubMed:26764011, ECO:0000269|PubMed:28727280}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14562095; 19001347; 20675578; 23042933; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,036 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |