| IED ID | IndEnz0002011707 |
| Enzyme Type ID | protease011707 |
| Protein Name |
26S proteasome regulatory subunit 6A homolog A 26S proteasome AAA-ATPase subunit RPT5a Proteasome 26S subunit 6A homolog A Regulatory particle triple-A ATPase subunit 5a Tat-binding protein 1 homolog A TBP-1 homolog A |
| Gene Name | RPT5A ATS6A.2 TBP1 At3g05530 F22F7.1 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MATPMVEDTSSFEEDQLASMSTEDITRATRLLDNEIRILKEDAQRTNLECDSYKEKIKENQEKIKLNKQLPYLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLKPGDLVGVNKDSYLILDTLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTKRFDSEVSGDREVQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQVQAKKKASLNYYA |
| Enzyme Length | 424 |
| Uniprot Accession Number | Q9SEI2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (Probable). Interacts with transit peptides of proteins targeted to the chloroplast, and may be involved in the degradation of unimported plastid protein precursors (PubMed:24846764). Plays a essential role in the gametophyte development (PubMed:19223514). Involved in tolerance to zinc deficiency, possibly through alleviation of oxidative stresses or processing of poly-ubiquitinated proteins (PubMed:21389614). {ECO:0000269|PubMed:19223514, ECO:0000269|PubMed:21389614, ECO:0000269|PubMed:24846764, ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 212..219; /note=ATP; /evidence=ECO:0000255 |
| Features | Chain (1); Cross-link (3); Initiator methionine (1); Modified residue (3); Nucleotide binding (1); Region (1); Sequence conflict (3) |
| Keywords | ATP-binding;Acetylation;Cytoplasm;Isopeptide bond;Nucleotide-binding;Nucleus;Phosphoprotein;Proteasome;Reference proteome;Stress response;Ubl conjugation |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9878390}. Nucleus {ECO:0000269|PubMed:9878390}. |
| Modified Residue | MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0007744|PubMed:22223895; MOD_RES 19; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9SEI4; MOD_RES 278; /note=O-acetylthreonine; /evidence=ECO:0000269|PubMed:20516081 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10363660; 11179422; 11742986; 11782485; 12692151; 15610358; 17028202; 17307927; 17825468; 18650403; 18775970; 20682047; 20706207; 21784786; 21798944; 27139926; 27247031; 31156663; 31249317; 32753431; 9741626; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,480 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |