| IED ID | IndEnz0002011762 |
| Enzyme Type ID | protease011762 |
| Protein Name |
Trypsin EC 3.4.21.4 |
| Gene Name | |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MKFLVILVLLGAAVAFEDDDKIVGGFTCAKNAVPYQVSLNAGYHFCGGSLINSQWVVSAAHCYKSRIQVRLGEHNIALNEGTEQFIDSQKVIKHPNYNSRNLDNDIMLIKLSTTARLSANIQSVPLPSACASAGTNCLISGWGNTLSSGTNYPDLLQCLNAPILTDSQCSNSYPGEITKNMFCAGFLAGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQRNYPGVYTKVCNFVTWIQSTISSN |
| Enzyme Length | 244 |
| Uniprot Accession Number | P70059 |
| Absorption | |
| Active Site | ACT_SITE 61; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 105; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 198; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; |
| DNA Binding | |
| EC Number | 3.4.21.4 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (6); Domain (1); Metal binding (3); Propeptide (1); Signal peptide (1); Site (1) |
| Keywords | Calcium;Digestion;Disulfide bond;Hydrolase;Metal-binding;Protease;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 26,080 |
| Kinetics | |
| Metal Binding | METAL 73; /note=Calcium; /evidence=ECO:0000250; METAL 75; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 83; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |