| IED ID | IndEnz0002011765 |
| Enzyme Type ID | protease011765 |
| Protein Name |
Dipeptidase verJ EC 3.4.13.19 Verticillin biosynthesis cluster protein J Fragment |
| Gene Name | verJ |
| Organism | Clonostachys rogersoniana |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Bionectriaceae Clonostachys Clonostachys rogersoniana |
| Enzyme Sequence | PIVSKMALLDDNLSKALKLLADVPLIDGHNDFPYFIRGWFPEQIDSLDCRNVRIAHTDLERLNQGRVGGVFWSAYVPCPDRHAKNDFVVDAQYESLRATMQQIDIIHTLIERYSDRLGLARTSSEVWEVFRSGRIASLIGVEGLHQIANSPGVMRNLYRLGVRYITLTHDSNNLYADSTNSSGPFHGGLSRDGISIVKEMNRIGMMVDLSHTSVATQKHVLAISKAPVIFSHSSCASVTEHPRNSPDDVLDMLKANGGVFMITFIRKPTDAESPTLEKVADHVQHVGDRIGYEHVGIGSDFDGVMLTASGLDDVSKFPLLIAELLKRGVSDHSIKNMIGLNVLRVMDSVEEVSMKMKETGEEMLHEVFEEIWDEKMRDEVRKTRDIFD |
| Enzyme Length | 388 |
| Uniprot Accession Number | A0A1U9YI27 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 169; /note=Substrate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10073; BINDING 243; /note=Substrate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10073; BINDING 300; /note=Substrate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10073 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid; Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869, ChEBI:CHEBI:77460; EC=3.4.13.19; Evidence={ECO:0000250|UniProtKB:Q4WMJ8}; |
| DNA Binding | |
| EC Number | 3.4.13.19 |
| Enzyme Function | FUNCTION: Dipeptidase; part of the gene cluster that mediates the biosynthesis of 11'-deoxyverticillin A, one of the dimeric epipolythiodioxopiperazines (ETPs) from the verticillin family that act as mycotoxins (PubMed:28376389). 11'-deoxyverticillin A is required for normal conidiation (PubMed:28376389). The nonribosomal peptide synthetase verP is speculated to be responsible for condensation of amino acids to form the carbon skeleton of verticillin, whereas the cluster-specific tailoring enzymes are involved in further modifications leading to the production of 11'-deoxyverticillin A (Probable). {ECO:0000269|PubMed:28376389, ECO:0000305|PubMed:28376389}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Mycotoxin biosynthesis. {ECO:0000269|PubMed:28376389}. |
| nucleotide Binding | |
| Features | Binding site (3); Chain (1); Erroneous gene model prediction (1); Metal binding (3); Non-terminal residue (1) |
| Keywords | Dipeptidase;Hydrolase;Metal-binding;Metalloprotease;Protease;Zinc |
| Interact With | |
| Induction | INDUCTION: Expression is regulated by the cluster-specific regulator verZ. {ECO:0000269|PubMed:29058652}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,458 |
| Kinetics | |
| Metal Binding | METAL 29; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10073; METAL 31; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10073; METAL 142; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10073 |
| Rhea ID | RHEA:48940 |
| Cross Reference Brenda |