| IED ID | IndEnz0002011797 |
| Enzyme Type ID | protease011797 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 16 EC 3.4.19.12 Deubiquitinating enzyme 16 Ubiquitin thioesterase 16 Ubiquitin-specific-processing protease 16 |
| Gene Name | ubp16 AN11684 |
| Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Nidulantes Emericella nidulans (Aspergillus nidulans) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Enzyme Sequence | MQEKPTTVAAYAAGASLAAVALFYVFGPNYTIDGDEAGGNRKKSIVGLSNPANDCFINSVLQALAGLGDLRLYLIRELHRRELDGPEIYNQLPGPEEADQLREKRPDRIRELQQGTITRALKEMLDRLNERPIYKKTISARAFIQALEFAYRTRISRNQQDAQEFLQIVAERLSDEYHAGVKARQRAEKSIEFNPYQEREEAPSEIEVRLDDGTENGLPAIIDTKLKEIDNEYGFPFEGKLESQIECQFCHYKYKPNQTSFVNLTLQVPQRSSTTLNACFDGLLKTEYIDDFRCDKCRLLHAIEVKSNALVKAGSATDRQRLEAEIEKIQLALSSDPENALDGVTLPPAELAPKRRIARHMRITVFPKIIAIHLSRSMFDRSGSTKNAAKVAFPERLPLGGILSQKWFKLLAIVCHKGSHNSGHYESFRRNHLYPPYSTPSVFSSYAQSRAASENPSRVASPRLPASSSSTEPPALNISPPASTSTNSPLSLTPDSPSRPPSATDLKSPRPTTSSSRVSFQSTHSSSKQTISPTSAARNSSSLDTARLSSPASRSSLAERNASATDTEASASASLASRIRRRRKTADRWWRISDEKIKECKTSDVLGMQKEVYLLFYEIEKSGS |
| Enzyme Length | 624 |
| Uniprot Accession Number | P0CAQ1 |
| Absorption | |
| Active Site | ACT_SITE 55; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 424; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Erroneous gene model prediction (1); Region (1) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 69,446 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |