| IED ID | IndEnz0002011803 |
| Enzyme Type ID | protease011803 |
| Protein Name |
Vesicle-associated membrane protein 3 VAMP-3 Cellubrevin CEB Synaptobrevin-3 |
| Gene Name | VAMP3 SYB3 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS |
| Enzyme Length | 100 |
| Uniprot Accession Number | Q15836 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Initiator methionine (1); Modified residue (1); Sequence conflict (1); Site (3); Topological domain (2); Transmembrane (1) |
| Keywords | Acetylation;Cell junction;Coiled coil;Direct protein sequencing;Membrane;Protein transport;Reference proteome;Synapse;Synaptosome;Transmembrane;Transmembrane helix;Transport |
| Interact With | Q8IVF2-3; Q9NVV5-2; Q13520; Q3SXY8; Q9BXK5; Q13323; J3KQ12; Q8WZ55; P11912; Q9H5X1; O95471; Q86T13; P21964; Q15125; Q9GZR5; P54852; Q9Y282; Q8TBP5; Q5JX71; Q96KR6; Q5T7V8; Q8TED1; Q92993; O95279; Q8TAF8; Q8TAP4-4; Q99735; O14880; O14524-2; Q13113; Q53GL0; O14684; Q86VR2; Q96TC7; Q9NR31; Q9NY72; Q15047-2; Q14973; O00161; O95721; Q16623; P32856-2; Q12846; Q96DZ7; Q53R12; Q96Q45-2; Q53FP2; Q4KMG9; Q8N661; Q6ZT21; Q9Y320; O43915; Q9H7M9; P61981; O55012 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}. |
| Modified Residue | MOD_RES 2; /note="N-acetylserine"; /evidence="ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712" |
| Post Translational Modification | PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120). {ECO:0000269|PubMed:22289120}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D. {ECO:0000269|PubMed:22289120, ECO:0000305}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120). {ECO:0000269|PubMed:22289120}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10037681; 10436022; 10445031; 10490598; 10508610; 10535736; 10542231; 10559861; 10559924; 10559959; 10618392; 10619026; 10625686; 10699464; 10724160; 10766823; 10873388; 10873802; 10958683; 10967094; 11082044; 11145705; 11185749; 11231140; 11239472; 11359012; 11470803; 11517213; 11532990; 11577110; 11696321; 11756552; 11773441; 11784792; 11803464; 11804587; 11809765; 11827983; 11889126; 11948177; 12057195; 12070132; 12130530; 12221077; 12242347; 12376551; 12456725; 12464619; 12480817; 12773384; 12860998; 12907671; 12952949; 14514689; 14622578; 14622579; 15037235; 15169870; 15252009; 15260957; 15260990; 15318165; 15502812; 15502813; 15649145; 15703209; 15814684; 15866170; 15895077; 16002401; 16103228; 16169070; 16189514; 16215232; 16326391; 16339170; 16410077; 16507994; 16516836; 1660188; 16630611; 16636067; 16702231; 16762923; 16798879; 16885419; 16903783; 16912714; 17018281; 17027967; 17028588; 17064668; 17158794; 17244649; 17269730; 17488291; 17512409; 17540576; 17583407; 17609109; 17681954; 17765681; 17916560; 17978091; 18006505; 18093523; 18158243; 18218625; 18347018; 18388313; 18628682; 18790740; 18829452; 18946081; 18981233; 19092055; 19159614; 19164740; 19234194; 19296720; 19458185; 19490898; 19534724; 19536138; 19557002; 19575674; 19603039; 19620288; 19696796; 19781582; 19910495; 20030946; 20033059; 20059951; 20101212; 20184954; 20231386; 20233848; 20416077; 20428113; 20448150; 20460433; 20591975; 20660154; 20679435; 20826345; 20851766; 20946875; 21094665; 21119010; 2115402; 21187331; 21278753; 21316588; 21351730; 21378159; 21421921; 21445324; 21482805; 21576392; 21613550; 21689688; 21699497; 21730051; 21779028; 21841790; 21911578; 21927000; 21927001; 21962517; 22099461; 22233676; 22505844; 22573826; 22608513; 22665057; 22734669; 22790947; 22970203; 22971344; 22992742; 23297414; 23353890; 23416715; 23536704; 23707487; 23813974; 23823722; 23861397; 23891661; 24128008; 24186068; 24355937; 24373201; 24581490; 24584464; 24659802; 24789820; 24850728; 24966051; 25002402; 25046114; 25083866; 25107275; 25209806; 25341920; 25343031; 25416956; 25668492; 25963737; 26034069; 26042225; 26299518; 26359495; 26496610; 26598554; 26638075; 27278019; 27791468; 28486133; 28524818; 28716920; 28825699; 28860633; 29146911; 29358323; 29510700; 30061681; 31105010; 31389670; 31871319; 32302585; 6146630; 7559638; 7877694; 7909812; 8107774; 8221884; 8440258; 8524399; 8543060; 8552632; 8571126; 8617235; 8620540; 8645157; 8662891; 8670801; 8756646; 8798539; 8805223; 8816443; 9013646; 9092476; 9100026; 9111050; 9177194; 9230071; 9405671; 9418861; 9427626; 9428629; 9535835; 9590177; 9635431; 9705280; 9736607; 9792683; 9822598; 9829970; 9843499; 9988689; |
| Motif | |
| Gene Encoded By | |
| Mass | 11,309 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |