| IED ID | IndEnz0002011823 |
| Enzyme Type ID | protease011823 |
| Protein Name |
Zinc metalloproteinase/disintegrin Cleaved into: Snake venom metalloproteinase SVMP EC 3.4.24.- ; Disintegrin halystatin-2 Fragment |
| Gene Name | |
| Organism | Gloydius halys (Chinese water mocassin) (Agkistrodon halys) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Gloydius Gloydius halys (Chinese water mocassin) (Agkistrodon halys) |
| Enzyme Sequence | SYEFSDCNENEYQTYVTDHSPQCILNDPLRPDTVSTPVSGNELLEAGEDCDCGAPANPCCDAATCKLRPGAQCAEGLCCDQCRFMKEGTICRMARGDDMDDYCNGISAGCPRNPFHA |
| Enzyme Length | 117 |
| Uniprot Accession Number | Q90221 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: [Snake venom metalloproteinase]: Impairs hemostasis in the envenomed animal. {ECO:0000250}.; FUNCTION: [Disintegrin halystatin-2]: Inhibits platelet aggregation and bone resorption. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (2); Disulfide bond (6); Domain (1); Motif (1); Non-terminal residue (1) |
| Keywords | Cell adhesion impairing toxin;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Platelet aggregation inhibiting toxin;Protease;Secreted;Toxin;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 95..97; /note=Cell attachment site |
| Gene Encoded By | |
| Mass | 12,686 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |