IED ID | IndEnz0002011844 |
Enzyme Type ID | protease011844 |
Protein Name |
Probable 26S proteasome non-ATPase regulatory subunit 3 26S proteasome subunit S3 Diphenol oxidase A2 component DOX-A2 Regulatory particle non-ATPase 3 |
Gene Name | Rpn3 Dox-A2 CG42641 |
Organism | Drosophila melanogaster (Fruit fly) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
Enzyme Sequence | MTNATDIGANDVEMEVDPTAETLADEKKNQDVAAVQEIREQIRQIEKGVASKESRFILRVLRNLPNTRRKLNGVVFRNLAQSIYPAGADREAAVALMPAVEKDATELPDVPKKQVATKAPIAEVDAYFYLLLLVKLIDASDLKRAGISADALMAKISIQNRRTLDLIGAKSYFYFSRVAELKNSLEGIRSFLHARLRTATLRNDFEGQAVLINCLLRNYLHYALYDQADKLVKKSVYPESASNNEWARFLYYLGRIKAAKLEYSDAHKHLVQALRKSPQHAAIGFRQTVQKLIIVVELLLGNIPERVVFRQAGLRQSLGAYFQLTQAVRLGNLKRFGDVVSQYGPKFQLDHTFTLIIRLRHNVIKTAIRSIGLSYSRISPQDIAKRLMLDSAEDAEFIVSKAIRDGVIEATLDPAQNFMRSKESTDIYSTREPQLAFHERISFCLNLHNQSVKAMRYPPKSYGKDLESAEERREREQQDLELAKEMAEDDEDGF |
Enzyme Length | 494 |
Uniprot Accession Number | P25161 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); Compositional bias (1); Domain (1); Region (1); Sequence conflict (1) |
Keywords | Proteasome;Reference proteome |
Interact With | |
Induction | |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 10628989; 10893261; 11779831; 11945175; 12408803; 14605208; 14652013; 15221030; 15854679; 15899868; 15946124; 17075830; 18550751; 18801354; 19277057; 19529778; 19581588; 20085633; 20371351; 20392747; 20813047; 21074052; 21251254; 21548953; 23071443; 23583758; 23790629; 24302569; 25152394; 25153327; 25294943; 25776889; 26252215; 26550828; 26870755; 27582081; 27956707; 3007281; 30426565; 3082714; 30837466; 3124532; 31555733; 31722958; 33242407; 33632744; 6425116; 8176361; 8543167; 8647399; 8683095; 9545464; 9605331; 9892357; |
Motif | |
Gene Encoded By | |
Mass | 56,004 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda | 3.4.25.1; |