Detail Information for IndEnz0002011844
IED ID IndEnz0002011844
Enzyme Type ID protease011844
Protein Name Probable 26S proteasome non-ATPase regulatory subunit 3
26S proteasome subunit S3
Diphenol oxidase A2 component
DOX-A2
Regulatory particle non-ATPase 3
Gene Name Rpn3 Dox-A2 CG42641
Organism Drosophila melanogaster (Fruit fly)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly)
Enzyme Sequence MTNATDIGANDVEMEVDPTAETLADEKKNQDVAAVQEIREQIRQIEKGVASKESRFILRVLRNLPNTRRKLNGVVFRNLAQSIYPAGADREAAVALMPAVEKDATELPDVPKKQVATKAPIAEVDAYFYLLLLVKLIDASDLKRAGISADALMAKISIQNRRTLDLIGAKSYFYFSRVAELKNSLEGIRSFLHARLRTATLRNDFEGQAVLINCLLRNYLHYALYDQADKLVKKSVYPESASNNEWARFLYYLGRIKAAKLEYSDAHKHLVQALRKSPQHAAIGFRQTVQKLIIVVELLLGNIPERVVFRQAGLRQSLGAYFQLTQAVRLGNLKRFGDVVSQYGPKFQLDHTFTLIIRLRHNVIKTAIRSIGLSYSRISPQDIAKRLMLDSAEDAEFIVSKAIRDGVIEATLDPAQNFMRSKESTDIYSTREPQLAFHERISFCLNLHNQSVKAMRYPPKSYGKDLESAEERREREQQDLELAKEMAEDDEDGF
Enzyme Length 494
Uniprot Accession Number P25161
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (1); Domain (1); Region (1); Sequence conflict (1)
Keywords Proteasome;Reference proteome
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10628989; 10893261; 11779831; 11945175; 12408803; 14605208; 14652013; 15221030; 15854679; 15899868; 15946124; 17075830; 18550751; 18801354; 19277057; 19529778; 19581588; 20085633; 20371351; 20392747; 20813047; 21074052; 21251254; 21548953; 23071443; 23583758; 23790629; 24302569; 25152394; 25153327; 25294943; 25776889; 26252215; 26550828; 26870755; 27582081; 27956707; 3007281; 30426565; 3082714; 30837466; 3124532; 31555733; 31722958; 33242407; 33632744; 6425116; 8176361; 8543167; 8647399; 8683095; 9545464; 9605331; 9892357;
Motif
Gene Encoded By
Mass 56,004
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.4.25.1;