Detail Information for IndEnz0002011871
IED ID IndEnz0002011871
Enzyme Type ID protease011871
Protein Name Snake venom metalloproteinase BITM02A
SVMP
EC 3.4.24.-
Gene Name
Organism Bothrops insularis (Golden lancehead) (Lachesis insularis)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops insularis (Golden lancehead) (Lachesis insularis)
Enzyme Sequence MIEVLLVTICLAAFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAVQPKYEDAMQYELKVNGEPVVLHLEKNKGLFSKDYSETHYSPDGREITTYPPVEDHCYYHGRIENDADSTASISACNGLKGHFKLQGETYLIEPLKLSDSEAHAVFKFENVEKEDEAPKMCGVTQNWESYEPIKKASQSNLTPEHQRYIELFIVVDHGMFMKYNGNSDKIRRRIHQMVNIMKEAYRYLYIDIALTGVEIWSNKDMINVQPAAPQTLDSFGEWRKTDLLNRKSHDNAQLLTNTDFDGPTIGLAYVGTMCDPKLSTGVIQDHSPINLLVAVTMAHELGHNLGISHDTDSCSCGGYSCIMAPEISHEPSKYFSDCSYIQCWDFIMKENPQCILNKRLRTDTVSTPVSGNELLEAGE
Enzyme Length 409
Uniprot Accession Number Q8QG89
Absorption
Active Site ACT_SITE 330; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095"
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Snake venom metalloproteinase that impairs hemostasis in the envenomed animal. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (3); Domain (1); Metal binding (12); Propeptide (2); Signal peptide (1)
Keywords Calcium;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Toxin;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 46,100
Kinetics
Metal Binding METAL 196; /note=Calcium 1; /evidence=ECO:0000250; METAL 280; /note=Calcium 1; /evidence=ECO:0000250; METAL 329; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 339; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 384; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250; METAL 387; /note=Calcium 1; /evidence=ECO:0000250; METAL 399; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250; METAL 402; /note=Calcium 2; /evidence=ECO:0000250; METAL 404; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250; METAL 406; /note=Calcium 2; /evidence=ECO:0000250; METAL 409; /note=Calcium 2; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda