| IED ID |
IndEnz0002011887 |
| Enzyme Type ID |
protease011887 |
| Protein Name |
Tetraspanin-12
|
| Gene Name |
tsp-12 T14G10.6 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MANRRQPVQHRAQQRVYRQSQIRYAPGAGGESEISCCVKYSVFSFNVIFFLLGFGLLLFGVWAQIEKNTFVNMLSKASKLYLDPTWPLLIVGFLTFIIGFSGCVGSLRENTSFLTFYSTLLGLLLIAEFSAGVFAYACRDQLDNYIRNLLNDVVVGYRDDPDLQLLIDSMQETWMCCGINGADDWDRNTYFSIEAREVASPEAGGVPFSCCINSSKLEFKNYFCGHGVRLKPESHMAAHLAAQRVMAHTASIYTEGCLPKLQLWLNNNMLLVAVSMVIIAIIQVLGICFAQNLKSDILAQRAKWYYTH |
| Enzyme Length |
308 |
| Uniprot Accession Number |
Q22495 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
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| EC Number |
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| Enzyme Function |
FUNCTION: Together with tsp-14, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling (PubMed:25978409, PubMed:28068334). May regulate BMP-like Sma/Mab signaling by mediating protease sup-17 trafficking to the cell surface (PubMed:28068334). Together with tsp-14, probably acts by modulating the activation of glp-1, a Notch-like receptor, to regulate germline maturation (PubMed:20220101). Probably acts by modulating the activation of lin-12, a Notch-like receptor, to regulate cell fate specification such as the anchor cell/ventral uterine precursor cell decision (PubMed:20220101). {ECO:0000269|PubMed:20220101, ECO:0000269|PubMed:25978409, ECO:0000269|PubMed:28068334}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Chain (1); Glycosylation (1); Topological domain (5); Transmembrane (4) |
| Keywords |
Cell membrane;Cytoplasmic vesicle;Glycoprotein;Membrane;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28068334}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28068334}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
12445390;
19372390;
21177967;
22560298;
23800452;
25487147;
31988138;
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| Motif |
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| Gene Encoded By |
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| Mass |
34,658 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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