| IED ID | IndEnz0002011907 |
| Enzyme Type ID | protease011907 |
| Protein Name |
Proteinase-activated receptor 1 PAR-1 Thrombin receptor |
| Gene Name | F2r Cf2r Par1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPRSFFLRNPSENTFELVPLGDEEEEEKNESVLLEGRAVYLNISLPPHTPPPPFISEDASGYLTSPWLTLFMPSVYTIVFIVSLPLNVLAIAVFVLRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAAFYGNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTRVPGLNITTCHDVLSENLMQGFYSYYFSAFSAIFFLVPLIVSTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLFLSDSPGTEAAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYSILCCKESSDPNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA |
| Enzyme Length | 430 |
| Uniprot Accession Number | P30558 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Glycosylation (3); Modified residue (1); Propeptide (1); Sequence conflict (5); Signal peptide (1); Site (1); Topological domain (8); Transmembrane (7) |
| Keywords | Blood coagulation;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Hemostasis;Membrane;Phosphoprotein;Receptor;Reference proteome;Signal;Transducer;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
| Modified Residue | MOD_RES 423; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P25116 |
| Post Translational Modification | PTM: Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG. {ECO:0000250|UniProtKB:P25116}.; PTM: Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10085414; 10591683; 10662791; 10952021; 11120874; 11154109; 11433347; 11533492; 11730935; 11850418; 11855866; 12370392; 12466851; 12869501; 12918424; 12954641; 14559973; 14573770; 14576054; 14610273; 14980205; 15031212; 15304051; 15345469; 15457341; 15475267; 15545995; 15582715; 15707570; 15723127; 15743797; 15818676; 15855637; 15858058; 16107646; 16391010; 16428450; 16434493; 16602821; 16710477; 16990608; 17027650; 17095716; 17122062; 17363687; 17397547; 17397548; 17431214; 17544303; 17596374; 17623652; 17893198; 17962354; 17965715; 17967980; 18000606; 18036193; 18268094; 18305483; 18347074; 18353977; 18398001; 18412955; 18474593; 18490515; 18606855; 18757438; 18802482; 18987429; 19012179; 19036971; 19079173; 19141861; 19162217; 19350118; 19401193; 19442625; 19625989; 19639229; 19687358; 19706295; 19815553; 19841542; 19941849; 20008134; 20067469; 20142268; 20152175; 20215560; 20223821; 20413722; 20436479; 20559570; 20945373; 21074454; 21149441; 21187389; 21267068; 21414931; 21591259; 21677750; 21859963; 21907177; 21940952; 22034512; 22306780; 22407318; 22521721; 22610965; 22771700; 22811450; 22952456; 23032873; 23062602; 23113835; 23202729; 23270594; 23391721; 23467409; 23516969; 23625915; 23637930; 23647384; 23708660; 23739922; 23814055; 23832758; 23982175; 24015257; 24239704; 24459330; 24475094; 24692104; 24740120; 24842054; 24866378; 25086265; 25165151; 25200274; 25261684; 25460576; 25575539; 25628003; 25649264; 25689283; 25733582; 25948816; 26020638; 26238780; 26436530; 26457757; 26463974; 26475502; 26783471; 26869387; 27145117; 27206851; 27613713; 27618774; 27771530; 27819671; 27820939; 27866874; 28122028; 28737512; 28882883; 29343482; 29599135; 29604205; 29622563; 29722565; 29777060; 29921916; 30152921; 30271984; 30385861; 30485646; 30566391; 30606478; 30690783; 30870413; 30995477; 31109956; 31434703; 31911460; 31977004; 32155135; 32212848; 32226307; 32408605; 33549720; 33681367; 33720950; 33798452; 8291612; 8621593; 8632823; 8661713; 8702939; 8828042; 8972001; 9358744; 9457168; 9722561; 9918574; 9931340; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,790 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |