| IED ID | IndEnz0002011949 |
| Enzyme Type ID | protease011949 |
| Protein Name |
Kunitz-type serine protease inhibitor DrKIn-II Daboia russelii Kunitz Inhibitor-II |
| Gene Name | |
| Organism | Daboia russelii (Russel's viper) (Vipera russelii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Viperinae (vipers) Daboia Daboia russelii (Russel's viper) (Vipera russelii) |
| Enzyme Sequence | MSSGGLLLLLGLLTLWAELTPISGHDRPTFCNLAPESGRCRAHLRRIYYNLESNKCEVFFYGGCGGNDNNFSTWDECRHTCVGK |
| Enzyme Length | 84 |
| Uniprot Accession Number | H6VC06 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor that inhibits plasmin (90%) (Ki=0.19 nM), trypsin (70%), FXIa/F11 (37%) (Ki=6 nM) and FXa/F10 (20%), and prolonges the activated partial thromboplastin time. This antifibrinolytic property has been confirmed by a fibrin plate assay. Shows less antifibrinolytic activity that aprotinin. In vivo, reduces the bleeding time in a murine bleeding model, and prevents the increase of fibrin(ogen) degradation products in coagulation-stimulated mice. {ECO:0000269|PubMed:22416129, ECO:0000269|PubMed:23999090}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (3); Domain (1); Signal peptide (1); Site (1) |
| Keywords | Disulfide bond;Hemostasis impairing toxin;Protease inhibitor;Secreted;Serine protease inhibitor;Signal;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 9,385 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |