| IED ID | IndEnz0002012001 |
| Enzyme Type ID | protease012001 |
| Protein Name |
Testisin EC 3.4.21.- Eosinophil serine protease 1 ESP-1 Serine protease 21 |
| Gene Name | PRSS21 ESP1 TEST1 UNQ266/PRO303 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGARGALLLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWPLLFFPLLWALPLLGPV |
| Enzyme Length | 314 |
| Uniprot Accession Number | Q9Y6M0 |
| Absorption | |
| Active Site | ACT_SITE 82; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 137; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 238; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Could regulate proteolytic events associated with testicular germ cell maturation. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (2); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (3); Lipidation (1); Natural variant (1); Propeptide (2); Signal peptide (1) |
| Keywords | Alternative splicing;Cell membrane;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Reference proteome;Serine protease;Signal;Zymogen |
| Interact With | P36952 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11072085; 15685234; 16810501; 19571264; 20211623; 21812934; 2443973; 25519908; 3422494; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,884 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |