| IED ID | IndEnz0002012006 |
| Enzyme Type ID | protease012006 |
| Protein Name |
Threonine aspartase 1 Taspase-1 EC 3.4.25.- Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta |
| Gene Name | TASP1 C20orf13 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MTMEKGMSSGEGLPSRSSQVSAGKITAKELETKQSYKEKRGGFVLVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVTAALVELEDSPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANRLLCEGQKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPNIMTTRFSLAAFKRNKRKLELAERVDTDFMQLKKRRQSSEKENDSGTLDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAENTGAHNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLASEDGVLGGVIVLRSCRCSAEPDSSQNKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGAVAGQSVAIEGGVCRLESPVN |
| Enzyme Length | 420 |
| Uniprot Accession Number | Q9H6P5 |
| Absorption | |
| Active Site | ACT_SITE 234; /note=Nucleophile; /evidence=ECO:0000305|PubMed:16216576 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.25.- |
| Enzyme Function | FUNCTION: Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). {ECO:0000250|UniProtKB:Q8R1G1, ECO:0000269|PubMed:14636557}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (4); Beta strand (14); Chain (2); Helix (11); Mutagenesis (2); Natural variant (2); Region (1); Sequence conflict (1); Turn (6) |
| Keywords | 3D-structure;Alternative splicing;Autocatalytic cleavage;Direct protein sequencing;Disease variant;Hydrolase;Protease;Reference proteome;Threonine protease;Zymogen |
| Interact With | Itself |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (6) |
| Cross Reference PDB | 2A8I; 2A8J; 2A8L; 2A8M; 6UGK; 6VIN; |
| Mapped Pubmed ID | 16537915; 18395097; 20516119; 21084304; 21418451; 22570686; 25996597; 26137584; 26657154; 28992066; 29097782; 29633245; 32071545; 33784495; 34012990; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,455 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |