| IED ID | IndEnz0002012007 |
| Enzyme Type ID | protease012007 |
| Protein Name |
Threonine aspartase 1 Taspase-1 EC 3.4.25.- Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta |
| Gene Name | Tasp1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MIMEKGMNSGEGLPSRSSQASAAKVTVKELETQQPCKEKRGGFVLVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVAAALVELEDSPFTNAGIGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVAHRLLCEGQKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPSTMTTRFSLAAFKRNKRKLELAERVETDFIQLKRRRQSSAKENDSGTLDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAENTGAQNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLACEDGVLGGVIVLRSCRCSSESDSSQDKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGAVAGQSVAIEGGVCRLESPVN |
| Enzyme Length | 420 |
| Uniprot Accession Number | Q8R1G1 |
| Absorption | |
| Active Site | ACT_SITE 234; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q9H6P5 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.25.- |
| Enzyme Function | FUNCTION: Protease responsible for KMT2A/MLL1 and KMT2D/MLL2 processing and activation (PubMed:16951254). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (PubMed:16951254). {ECO:0000250|UniProtKB:Q9H6P5, ECO:0000269|PubMed:16951254}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (2); Chain (2); Compositional bias (1); Erroneous initiation (1); Region (1) |
| Keywords | Alternative splicing;Hydrolase;Protease;Reference proteome;Threonine protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 12904583; 14610273; 1711220; 18395097; 18799693; 21677750; 22166309; 23934123; 24176642; 25267403; 25664857; 27480124; 30573454; 34156981; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,360 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |