| IED ID |
IndEnz0002012014 |
| Enzyme Type ID |
protease012014 |
| Protein Name |
Tumor necrosis factor receptor superfamily member 1A
Tumor necrosis factor receptor 1
TNF-R1
Tumor necrosis factor receptor type I
TNF-RI
TNFR-I
p55
p60
CD antigen CD120a
|
| Gene Name |
Tnfrsf1a Tnfr-1 Tnfr1 |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR |
| Enzyme Length |
454 |
| Uniprot Accession Number |
P25118 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (12); Domain (1); Glycosylation (4); Region (1); Repeat (4); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords |
Apoptosis;Cell membrane;Disulfide bond;Glycoprotein;Golgi apparatus;Membrane;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With |
Q9EQY0; Q60855; Q31125; P62991; P01375 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: (Microbial infection) Glycosylated at Arg-376 by S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. {ECO:0000269|PubMed:30902834}. |
| Signal Peptide |
SIGNAL 1..29; /evidence=ECO:0000250|UniProtKB:P19438 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10051620;
10064079;
10072530;
10077625;
10101016;
10195744;
10195897;
10201952;
10201999;
10204494;
10225939;
10319026;
10329594;
10329607;
10338499;
10339421;
10339588;
10359811;
10377141;
10414954;
10415063;
10441735;
10442092;
10449438;
10463949;
10490988;
10500078;
10509653;
10510085;
10510391;
10514013;
10514016;
10521784;
10570011;
10583962;
10595943;
10606630;
10614649;
10615069;
10620118;
10623807;
10623822;
10657611;
10666158;
10666256;
10671227;
10678933;
10678956;
10687308;
10702263;
10702415;
10706852;
10708760;
10749768;
10779546;
10781441;
10793093;
10801288;
10805971;
10843380;
10848737;
10861087;
10864873;
10878503;
10884431;
10898787;
10899912;
10926756;
10940914;
10946295;
10946317;
10992477;
10996392;
11002334;
11034606;
11046001;
11046004;
11046015;
11067918;
11069072;
11076794;
11078604;
11120777;
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11181695;
11217851;
11226278;
11238652;
11239407;
11241200;
11245629;
11264022;
11290332;
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11290803;
11292619;
11309656;
11342599;
11342601;
11358427;
11359380;
11374864;
11401847;
11416016;
11438547;
11447117;
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11466381;
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11493610;
11517251;
11544288;
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11714812;
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11739237;
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11751996;
11752172;
11753206;
11777546;
11792852;
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11801629;
11805150;
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11890668;
11909948;
11917000;
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11994450;
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12000727;
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12087057;
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12540559;
12560241;
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12609491;
12630518;
12663667;
12692538;
12695514;
12706861;
12734369;
12736263;
12750352;
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12801416;
12805214;
12810684;
12837754;
12842828;
12865254;
12887831;
12927619;
12933830;
12933876;
12939259;
12944486;
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12960267;
12968667;
1315717;
1322446;
1427910;
14525729;
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14557383;
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14610273;
14617571;
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14635056;
14645573;
14661063;
14697498;
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14724177;
14732063;
14745712;
14749364;
14755337;
14764724;
14961564;
14966082;
14973251;
15044707;
15047807;
15051641;
15102471;
15142358;
15153503;
15153508;
15175328;
15187147;
15210743;
15247912;
15280422;
15289505;
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15304346;
15315973;
15317681;
15322543;
15334086;
15349890;
15351786;
15358232;
15366373;
15368276;
15368449;
15389885;
15470024;
15495792;
15498030;
15514106;
15528353;
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15585839;
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15608149;
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15611291;
15614439;
15615879;
15619234;
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15654822;
15661932;
15664785;
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15668736;
15670651;
15673605;
15685547;
15698630;
15699216;
15708985;
15721320;
15744305;
15767369;
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15845519;
15845526;
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15894588;
15905851;
15908387;
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16027239;
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16079187;
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17500068;
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17724122;
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17925397;
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17959902;
17979156;
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18022363;
18025217;
18097003;
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18219394;
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18382767;
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18390708;
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18413601;
18430733;
18442881;
18452158;
18461160;
18463260;
18464930;
18467504;
18483211;
18490660;
18493257;
18505433;
18515164;
18535181;
18538734;
18544042;
18549896;
18559949;
18566103;
18606667;
18606695;
18612394;
18621737;
18628255;
18632856;
18641654;
18660426;
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18713739;
18719121;
18728678;
18768889;
18772111;
18799693;
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18815054;
18824172;
18824767;
18825372;
18830417;
18838275;
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18931327;
18940942;
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19004989;
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19050279;
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19201910;
19208810;
19211506;
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19234607;
19246648;
19255345;
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19285115;
19289507;
19303389;
19323909;
19380791;
19403643;
19435851;
19477937;
19479048;
19494115;
19494310;
19516260;
19519169;
19531269;
19535637;
19546478;
19582157;
19590497;
19608869;
19625730;
19626033;
19635911;
19641494;
19648283;
19681056;
19720838;
19741298;
19759514;
19772956;
19783685;
19788501;
19800575;
19815541;
19842848;
19858212;
19890995;
19907077;
19913791;
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19927158;
19931338;
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19941340;
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20005846;
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20042666;
20056718;
20080755;
20093491;
20145121;
20146926;
20156456;
20160664;
20212506;
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20417692;
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20519121;
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20534702;
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20628198;
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20685290;
20713516;
20739394;
20810989;
20826683;
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20870942;
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20926563;
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21070800;
21074606;
21098094;
21145890;
21148330;
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21266511;
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21268004;
21278344;
21278350;
21282379;
21307132;
21320567;
21378027;
21383240;
21393251;
21393509;
21402942;
21410936;
21419662;
21427409;
21464320;
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21515659;
21518864;
21519143;
21523796;
21526210;
21602809;
21603208;
21621534;
21626455;
21641402;
21653902;
21658601;
21668898;
21670171;
21677750;
21709152;
21734073;
21737776;
21768269;
21768400;
21802165;
21825016;
21835156;
21867719;
21880915;
21911709;
21912643;
21926986;
21930713;
21957083;
21982949;
21987217;
21989628;
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22000287;
22011580;
22016541;
22052013;
22075779;
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22212899;
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7540941;
7561085;
7566090;
7579385;
7594541;
7595529;
7613032;
7631899;
7636251;
7737295;
7758105;
7836916;
7873786;
7911121;
7957572;
7964164;
7990930;
8060345;
8105477;
8138038;
8169842;
8380565;
8387893;
8395024;
8396415;
8586432;
8609380;
8638112;
8642347;
8662983;
8673925;
8690462;
8691140;
8699412;
8752935;
8757341;
8808629;
8816431;
8824198;
8824264;
8910423;
8921956;
9024154;
9037072;
9099731;
9124479;
9125577;
9144497;
9159143;
9164935;
9169139;
9176705;
9177215;
9203538;
9221791;
9247583;
9294124;
9324050;
9324362;
9335502;
9337398;
9368614;
9396768;
9435232;
9463397;
9464804;
9485205;
9498737;
9501881;
9531303;
9536117;
9551933;
9551964;
9552007;
9570552;
9605154;
9620596;
9620659;
9625757;
9637537;
9647244;
9664082;
9675420;
9686610;
9688988;
9697836;
9705956;
9725234;
9736029;
9737713;
9754555;
9755232;
9763613;
9769336;
9783914;
9820556;
9832419;
9843922;
9846974;
9858438;
9892622;
9894568;
9914339;
9916934;
9916988;
9973400;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
50,130 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|