| IED ID | IndEnz0002012034 |
| Enzyme Type ID | protease012034 |
| Protein Name |
Thrombin-like enzyme albolabrase SVTLE albolabrase EC 3.4.21.- Fibrinogen-clotting enzyme Snake venom serine protease SVSP Fragment |
| Gene Name | |
| Organism | Trimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Trimeresurus Trimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris) |
| Enzyme Sequence | VVGGDECNINE |
| Enzyme Length | 11 |
| Uniprot Accession Number | P0DJF4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Thrombin-like snake venom serine protease. Releases both fibrinopeptides A and B after 90 min incubation, but only fibrinopeptides A after 10 min incubation. Clots fibrinogen with different clotting time depending on the species: bovine > dog = human > goat. Fails to clot both rabbit and cat fibrinogens. {ECO:0000269|PubMed:21983189}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Non-terminal residue (1) |
| Keywords | Blood coagulation cascade activating toxin;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Protease;Secreted;Serine protease;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,148 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.11 mM for N-benzoyl-L-Pro-L-Phe-L-Arg p-nitroanilide {ECO:0000269|PubMed:21983189}; KM=0.13 mM for N-benzoyl-L-Phe-L-Val-L-Arg p-nitroanilide {ECO:0000269|PubMed:21983189}; KM=0.31 mM for N-benzoyl-L-Val-L-Gly-L-Arg p-nitroanilide {ECO:0000269|PubMed:21983189}; KM=0.35 mM for N-p-tosyl-Gly-L-Pro-L-Lys p-nitroanilide {ECO:0000269|PubMed:21983189}; KM=0.61 mM for N-alpha-benzoyl-L-arginine ethyl ester (BAEE) {ECO:0000269|PubMed:21983189}; |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |