| IED ID |
IndEnz0002012162 |
| Enzyme Type ID |
protease012162 |
| Protein Name |
Kunitz-type serine protease inhibitor bicolin
|
| Gene Name |
|
| Organism |
Vespa bicolor (Black shield wasp) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Hymenoptera
Apocrita (wasps
ants
and bees)
Aculeata
Vespoidea
Vespidae (wasps)
Vespinae (hornets and yellowjackets)
Vespa
Vespa bicolor (Black shield wasp)
|
| Enzyme Sequence |
MNAKILALLIGVVFVGLFTVSTPAHPLCLLDPPFGFCQSSISRFAPVVGKCREYIYGGCSGKANNFQAQAKCQANCG |
| Enzyme Length |
77 |
| Uniprot Accession Number |
C0LNR2 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Serine protease inhibitor that inhibits trypsin (Ki=550 nM) and thrombin (Ki=26000 nM). Exerts anticoagulant activity probably by the way of inhibiting thrombin. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (3); Domain (1); Signal peptide (1); Site (1) |
| Keywords |
Blood coagulation cascade inhibiting toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Protease inhibitor;Secreted;Serine protease inhibitor;Signal;Toxin |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..24 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
8,141 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|