| IED ID |
IndEnz0002012219 |
| Enzyme Type ID |
protease012219 |
| Protein Name |
Putative inactive serine protease 43
|
| Gene Name |
Prss43 Tessp3 |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MGGFCGADRGGFLALLVWLQLLQPLFSGTYKPREDSGVMHRPQRPRRPRSDPEAPAQQSRLKSLSISHPSGVPVSVDRTEIPGSGSPSGTTTKITLENRRSSLGGPFFTDTCGHRITEVDPGSLSAGRKWPWQVSLQSQNEHVCGGSLISHRWVLTAAHCIYEQEEYMVMLGDDMLHSESESVTLVPVQDIIFPSNFDIQTMRNDIALALLYFPVNYSSLIQPVCLPEEPFRVKNGTVCWVTGWGQQNEIDAGFASILLQEVQQRILLQKHCNTLFQRQLGTSKNLVIKGMICGLQDSGQSLCWGDSGNPLVCESDNTWTQVGIMSWGINCNGVPVLSVYTDIAEYNEWVSYVLSQASRMDPMGVLVLYLSLVFPLALLVAL |
| Enzyme Length |
382 |
| Uniprot Accession Number |
Q76HL1 |
| Absorption |
|
| Active Site |
ACT_SITE 159; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 205; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274; ACT_SITE 307; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU00274 |
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. {ECO:0000269|PubMed:23536369}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Active site (3); Chain (1); Compositional bias (3); Disulfide bond (4); Domain (1); Region (1); Signal peptide (1); Transmembrane (1) |
| Keywords |
Cell membrane;Differentiation;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Reference proteome;Signal;Spermatogenesis;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23536369}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23536369}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
21267068;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
42,203 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|