| IED ID | IndEnz0002012234 |
| Enzyme Type ID | protease012234 |
| Protein Name |
Tubulin beta-2 chain Beta-2-tubulin |
| Gene Name | tbb-2 C36E8.5 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MREIVHVQAGQCGNQIGSKFWEVISDEHGIQPDGTFKGETDLQLERIDVYYNEANNGKYVPRAVLVDLEPGTMDSVRSGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVIRKEAEGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSSFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICYRTLKLTNPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLSAKGTQAYRALTVAELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMREVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFVGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLISEYQQYQEATAEDDVDGYAEGEAGETYESEQ |
| Enzyme Length | 450 |
| Uniprot Accession Number | P52275 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 140..146; /note=GTP; /evidence=ECO:0000255 |
| Features | Chain (1); Compositional bias (1); Mutagenesis (4); Nucleotide binding (1); Region (1) |
| Keywords | 3D-structure;Cytoplasm;Cytoskeleton;GTP-binding;Microtubule;Nucleotide-binding;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. |
| Modified Residue | |
| Post Translational Modification | PTM: Cleaved by caspase ced-3 in vitro. {ECO:0000269|PubMed:17371877}. |
| Signal Peptide | |
| Structure 3D | Electron microscopy (1) |
| Cross Reference PDB | 6E88; |
| Mapped Pubmed ID | 11099034; 11408582; 12937270; 14551910; 14565976; 15083533; 15084750; 15338614; 15489339; 15791247; 15990870; 16854972; 17090602; 17486083; 17669650; 17850180; 17897480; 18182484; 18640159; 19368797; 19922876; 20300184; 20308279; 20599896; 21177967; 21390299; 21533050; 21900274; 22103665; 22560298; 22634595; 22918439; 23800452; 25437307; 25487147; 26912668; 27654945; 28285997; 28302908; 28636662; 29348603; 30245157; 31216475; 31242766; 31283754; 7607073; |
| Motif | |
| Gene Encoded By | |
| Mass | 50,345 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |