| IED ID | IndEnz0002012235 |
| Enzyme Type ID | protease012235 |
| Protein Name |
Tissue factor TF Coagulation factor III CD antigen CD142 |
| Gene Name | F3 Cf3 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MAIPMRPRLLAALAPTFLGFLLLQVAVGAGTPPGKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKYKCTGTTDTECDLTDEIVKDVNWTYEARVLSVPWRNSTHGKETLFGTHGEEPPFTNARKFLPYRDTKIGQPVIQKYEQGGTKLKVTVKDSFTLVRKNGTFLTLRQVFGNDLGYILTYRKDSSTGRKTNTTHTNEFLIDVEKGVSYCFFAQAVIFSRKTNHKSPESITKCTEQWKSVLGETLIIVGAVVFLVTVFIILLTISLCKRRKNRAGQKRKNTPSRLA |
| Enzyme Length | 295 |
| Uniprot Accession Number | P42533 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Glycosylation (6); Lipidation (1); Motif (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Blood coagulation;Disulfide bond;Glycoprotein;Hemostasis;Lipoprotein;Membrane;Palmitate;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P13726}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P13726}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..28; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10190887; 10780328; 10840019; 11750579; 12083485; 15293323; 15481788; 16113797; 16902157; 18315926; 19458308; 21229253; 21396682; 21423288; 21964405; 22140576; 24831016; 25772383; 25883098; 26311287; 26370456; 9426395; 9875493; 9916935; 9974408; |
| Motif | MOTIF 246..248; /note=WKS motif |
| Gene Encoded By | |
| Mass | 33,444 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |