| IED ID | IndEnz0002012259 |
| Enzyme Type ID | protease012259 |
| Protein Name |
Tissue factor pathway inhibitor 2 TFPI-2 Placental protein 5 PP5 |
| Gene Name | TFPI2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF |
| Enzyme Length | 235 |
| Uniprot Accession Number | P48307 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. {ECO:0000269|PubMed:7872799}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (3); Chain (1); Disulfide bond (9); Domain (3); Glycosylation (2); Helix (2); Natural variant (2); Sequence conflict (4); Signal peptide (1); Site (3); Turn (1) |
| Keywords | 3D-structure;Alternative splicing;Blood coagulation;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemostasis;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence="ECO:0000269|PubMed:3276312, ECO:0000269|PubMed:7872799" |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1ZR0; |
| Mapped Pubmed ID | 11840337; 12606321; 12632077; 12738994; 12757776; 12787920; 12876637; 12881707; 12921785; 14525759; 14558946; 14623891; 14678821; 14970225; 14983234; 15183047; 15221977; 15231748; 15467913; 15592528; 15685245; 16247609; 16580726; 16641089; 16965396; 17023682; 17138934; 17352822; 17372906; 17464989; 17558445; 18053161; 18097563; 18401718; 18480470; 18810851; 19081094; 19102937; 19103149; 19212621; 19288010; 19435926; 19571260; 19763915; 19902129; 19936309; 20015200; 20018303; 20113832; 20347477; 20377370; 20530429; 20537494; 21036731; 21062455; 21224345; 21515313; 21530612; 21621497; 21820798; 21983100; 21984372; 22052167; 22110206; 22203034; 22208663; 22232300; 22399594; 22449186; 23032906; 23108564; 23300768; 23497249; 24591127; 25036127; 25179542; 25262870; 25414083; 25755719; 25755762; 25902909; 25973077; 26313014; 26318044; 27797450; 27798689; 27840051; 28039717; 28088469; 28208084; 28351398; 29051606; 29845195; 30028057; 30254643; 30258071; 30442884; 30591460; 30651599; 30803712; 31405379; 31839043; 31984574; 32132611; 32196834; 32248791; 32559232; 32891505; 34009487; 34184357; 34502355; |
| Motif | |
| Gene Encoded By | |
| Mass | 26,934 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |