IED ID | IndEnz0002012260 |
Enzyme Type ID | protease012260 |
Protein Name |
Thrombin inhibitor subunit 1 Thrombin inhibitor subunit I Fragment |
Gene Name | |
Organism | Bothrops jararaca (Jararaca) (Bothrops jajaraca) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops jararaca (Jararaca) (Bothrops jajaraca) |
Enzyme Sequence | EKFPAVNQKPQAAXL |
Enzyme Length | 15 |
Uniprot Accession Number | P84026 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Binds to thrombin and inhibits blood coagulant activity. Does not inhibit the serine protease activity of thrombin or platelet aggregation activity. May bind to the heparin recognition exosite. {ECO:0000269|PubMed:12927776, ECO:0000303|PubMed:12927776}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); Non-terminal residue (1) |
Keywords | Blood coagulation cascade inhibiting toxin;Direct protein sequencing;Glycoprotein;Hemostasis impairing toxin;Secreted;Toxin |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12927776}. |
Modified Residue | |
Post Translational Modification | PTM: Glycosylated. {ECO:0000269|PubMed:12927776}. |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 1,652 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |