Detail Information for IndEnz0002012260
IED ID IndEnz0002012260
Enzyme Type ID protease012260
Protein Name Thrombin inhibitor subunit 1
Thrombin inhibitor subunit I
Fragment
Gene Name
Organism Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Enzyme Sequence EKFPAVNQKPQAAXL
Enzyme Length 15
Uniprot Accession Number P84026
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Binds to thrombin and inhibits blood coagulant activity. Does not inhibit the serine protease activity of thrombin or platelet aggregation activity. May bind to the heparin recognition exosite. {ECO:0000269|PubMed:12927776, ECO:0000303|PubMed:12927776}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Non-terminal residue (1)
Keywords Blood coagulation cascade inhibiting toxin;Direct protein sequencing;Glycoprotein;Hemostasis impairing toxin;Secreted;Toxin
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12927776}.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000269|PubMed:12927776}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 1,652
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda