| IED ID | IndEnz0002012290 |
| Enzyme Type ID | protease012290 |
| Protein Name |
Transmembrane protease serine 11A EC 3.4.21.- Airway trypsin-like protease 1 Serine protease DESC3 DESC-3 |
| Gene Name | Tmprss11a Desc3 Gm7 Hatl1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEVAGYGTHNRDLKQWMVTLLSALSLMMVVVTIGLLALFLVFDIQVNSNSGQKSSNQLKDLQETNENLVDEIFIDSALNNRYIKNHVVGLTPEEDDTKADIVMVFQPPATGRRTVGKKTHHSILDQKTRNARALPADVSLVQVKDCGKRAIPLIANRIVSGNPAAKGAWPWQVSLQRSNIHQCGGTLIGNMWVVTAAHCFRTNSNPRQWTLSFGTTINPPLMKRDVRRIIMHERYRPPARDHDIALVQFSPRVTFSDEVRRICLPEPSASFPPNSTVYITGFGALYYGGESQNELREARVQIISNDICKKRHVYGNEIKRGMFCAGFLEGNYDACRGDSGGPLVIRDNKDTWYLIGIVSWGDNCGQKNKPGVYTQVTYYRHWIASKTGL |
| Enzyme Length | 389 |
| Uniprot Accession Number | Q3UQ41 |
| Absorption | |
| Active Site | ACT_SITE 198; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 243; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 339; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Domain (2); Glycosylation (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cell cycle;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 21853097; 29976755; 31501243; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,605 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |