| IED ID | IndEnz0002012372 |
| Enzyme Type ID | protease012372 |
| Protein Name |
Pro-apoptotic serine protease NMA111 EC 3.4.21.- 111 kDa nuclear mediator of apoptosis |
| Gene Name | NMA111 YNM3 YNL123W N1897 |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MTISLSNIKKRDHSKISDGTSGESSLVKRKQLESATGDQEEEYTDHEIIIEPLHFANNNNTVLTDSENYLRWQNTISNVVKSVVSIHFSQVAPFDCDSALVSEATGFVVDAKLGIILTNRHVVGPGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAKFPENIGLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQLVIQRGGVECTVTCTVGDLHAITPHRYVEVCGATFHELSYQMARFYALPVRGVFLSSASGSFNFDSKERVGWIVDSIDNKETPDLDTFIEIMKTIPDRKRVTVRYHHLTDQHSPLVTSIYIDRHWCNEFRVYTRNDTTGIWDYKNVADPLPADALKPRSAKIIPIPVNNEKVAKLSSSLCTVATMAAVPLDSLSADILKTSGLIIDAEKGYVLVSRRVVPHDCLDTFVTIADSLVVPATVEFLHPTHNFAIVKYDPELVKAPLITPKLSTTRMKRGDKLQFIGFTQNDRIVTSETTVTDISSVSIPSNLIPRYRATNLEAISIDCNVSTRCNSGILTDNDGTVRGLWLPFLGERLENKEKVYLMGLDIMDCREVIDILKNGGKPRVSIVDAGFGSISVLQARIRGVPEEWIMRMEHESNNRLQFITVSRVSYTEDKIHLETGDVILSVNGKLVTEMNDLNGVVSSADGILPSAMLDFKVVRDGNIVDLKIKTVEVQETDRFVIFAGSILQKPHHAVLQAMVDVPKGVYCTFRGESSPALQYGISATNFITHVNEIETPDLDTFLKVVKTIPDNSYCKMRLMTFDNVPFAISLKTNYHYFPTAELKRDNITHKWIEKEFTGNSQSEK |
| Enzyme Length | 997 |
| Uniprot Accession Number | P53920 |
| Absorption | |
| Active Site | ACT_SITE 121; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 152; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 235; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1. {ECO:0000269|PubMed:14645503, ECO:0000269|PubMed:14657274, ECO:0000269|PubMed:16608876}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (2); Mutagenesis (1); Natural variant (10); Region (2) |
| Keywords | Apoptosis;Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14657274}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10953080; 14534547; 15527405; 15556039; 16361226; 16470384; 17087770; 17101700; 17207637; 18342634; 18782613; 18946088; 19250922; 19416362; 19808885; 19930686; 20950655; 21814286; 21836634; 21886177; 21936841; 21936842; 22094424; 22783546; 22817540; 23656787; 24040173; 24103154; 24205865; 24437935; 25483081; 26272996; 26636650; 27048816; |
| Motif | |
| Gene Encoded By | |
| Mass | 110,881 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |