| IED ID | IndEnz0002012382 |
| Enzyme Type ID | protease012382 |
| Protein Name |
Vacuolar membrane protease EC 3.4.-.- FXNA-related family protease 1 |
| Gene Name | PMAA_024220 |
| Organism | Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Trichocomaceae Talaromyces Talaromyces sect. Talaromyces Talaromyces marneffei (Penicillium marneffei) Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
| Enzyme Sequence | MARSRTAGRCNPFAFYRVPVTVFVTLIYVALLAPIIVVHHILPAVPESDVEGLDLHEAWRDLQHLTNGFHPYNSHKNDEVRSWLLTRIDEIVSTNVKDAKQQDGVRTFVFDDNQSNLTVVQSNLGVYFEGTNIIVYICGQEDDKREWWKEPGLSPSGKGGVLVNAHYDSVSTGYGATDDGVGVISCLQLIKYFTTPGHEPTRGLVVLLNNGEEDFLNGARVYSQHPISKLPHTFLNLEGAGAGGRATLFRSSDTEVTKFYQRSPYPFGSVFSDAGFKLGMIRSQTDYIVFEGDMGLRGLDVAFMEPRARYHTNQDDAKHTSQQSLWHMLSAAVATTEGLVSDTSHDFEGRPQGPGKVPSGTGSGAVWFDLFGTAFAVFEIHTLFALSVTLLIVGPLTLFITSIILANQDRMYLFGISVPVDDGFGSVPLRGWRGFFRFPFIFGSTTASVVALAYLMAKINPMIAHSSEYAVWSMMISAWVFVAWFLSRIANFARPSALHRIYVLTWMFLLTWVLLVITTVYENRDGIASGYFVIFYAFGTFMATWISYLELFSLPKKSDFANKVSGQISSRPTSLGGSRLLTPSGESVGQHPEDEEPTESTSLLRGQRTSFANYTRPVEDDGDGDLLSTGVSTDVSEARDFNVYGYEQPWSANLPKWTWILQFLLIAPIVIILIGQLGLLITSAIHQTMQDGSSTLVPYLIIALLTTFLFMPTLPFIHRYTYHIPTFLFLIFVATLVYNLVAFPFSGNNRTKLFFLQEVDLDTGANRVSLTGIQPFVSDAVASIPSADGQNISCIPKMDRTECSWESSLVPHVITHPGSEKEETPLNEWVKYKATRLEPGSQNSNRAQIKISGLNTRGCLLHFDKPITRFHVTGSAIDSRFPSNPSLEDGTEDGVREIRLWSRTWGNQWVVDAEWASDEDVNNEEDTLTGKATCLWSDANTQGAIPALDEVIQYSPDWVAITKLDAGLVKGSRSFEV |
| Enzyme Length | 977 |
| Uniprot Accession Number | B6Q656 |
| Absorption | |
| Active Site | ACT_SITE 212; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Glycosylation (4); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 108,491 |
| Kinetics | |
| Metal Binding | METAL 166; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 178; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 178; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 213; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 238; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 311; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |