| IED ID | IndEnz0002012481 |
| Enzyme Type ID | protease012481 |
| Protein Name |
Dorsal-ventral patterning protein tolloid EC 3.4.24.- |
| Gene Name | tld CG6868 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MKGMRLMPMKMKAKLVVLSVGALWMMMFFLVDYAEGRRLSQLPESECDFDFKEQPEDFFGILDSSLVPPKEPKDDIYQLKTTRQHSGRRRKQSHKSQNKAALRLPPPFLWTDDAVDVLQHSHSPTLNGQPIQRRRRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVKNCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLELGQRKRLSRGDIVQANLLYKCASCGRTYQQNSGHIVSPHFIYSGNGVLSEFEGSGDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLVRRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKDQSIDSPNYPMDYMPDKECVWRITAPDNHQVALKFQSFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIKTRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGKTCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFHYTKCNYDYLIIYSKMRDNRLKKIGIYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDVDECSMNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVLGHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAGLQRKGFKATFVSECGGYLRATNHSQTFYSHPRYGSRPYKRNMYCDWRIQADPESSVKIRFLHFEIEYSERCDYDYLEITEEGYSMNTIHGRFCGKHKPPIIISNSDTLLLRFQTDESNSLRGFAISFMAVDPPEDSVGEDFDAVTPFPGYLKSMYSSETGSDHLLPPSRLI |
| Enzyme Length | 1067 |
| Uniprot Accession Number | P25723 |
| Absorption | |
| Active Site | ACT_SITE 232; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Required for normal dorsal development. TLD may interact physically with DPP-C protein. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (19); Domain (8); Erroneous initiation (2); Glycosylation (8); Metal binding (3); Motif (2); Propeptide (1); Signal peptide (1) |
| Keywords | Calcium;Cleavage on pair of basic residues;Developmental protein;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..36; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10199954; 10201364; 10201373; 10393112; 10449357; 10498935; 10502111; 10570989; 10602463; 10733523; 10757786; 10769238; 10819541; 10823947; 10950309; 10996808; 11144283; 11157786; 11159907; 11222150; 11256063; 11260716; 11290316; 11420372; 11432817; 11532914; 11598015; 11700289; 11782317; 11967165; 11992721; 12050111; 12200166; 12223399; 12225917; 12239569; 12364792; 12464180; 12835400; 12925593; 12930747; 12930748; 1299363; 1339338; 1339676; 1340472; 1349523; 14550792; 14605208; 14642751; 14731500; 15082551; 15135065; 15261661; 15380237; 15601817; 15716118; 15759004; 15781702; 15788537; 15795372; 15797386; 15872004; 15916937; 15935780; 16041756; 1618130; 1618145; 16198288; 16368928; 16488892; 16780828; 16781701; 16864795; 16971470; 17119021; 17322397; 17336283; 1765005; 1814368; 18539121; 18931655; 1905816; 19884260; 19884307; 20159596; 20220848; 20371351; 2068782; 20813047; 21074052; 21086136; 2112301; 21245164; 21383317; 21461680; 21684629; 21814502; 21839924; 21890896; 22150153; 22152945; 22737084; 22913798; 23071443; 23092796; 23107453; 23172856; 23369355; 23698094; 23699410; 23868318; 23951546; 24086079; 24157250; 24349561; 24680699; 24813173; 24896182; 25009057; 2511071; 25642644; 26113727; 26440503; 26684043; 27172210; 27357258; 27501451; 27979994; 28130362; 28305338; 28853393; 29432195; 30355725; 32143742; 32901612; 32994163; 33543035; 7552158; 7579524; 7697337; 7705627; 7705656; 7774017; 7813777; 7893745; 7906442; 7950318; 7958834; 7958918; 7958919; 8086336; 8125188; 8264640; 8536976; 8553073; 8682290; 8791536; 8825480; 8830723; 8889525; 8918893; 9053307; 9151690; 9182755; 9187140; 9223224; 9232597; 9283598; 9363950; 9435287; 9446747; 9454330; 9545464; 9584097; 9621427; 9654011; 9670811; 9712300; 9729721; 9735359; 9827802; 9851920; 9851980; 9876186; |
| Motif | MOTIF 245..247; /note=Cell attachment site; /evidence=ECO:0000255; MOTIF 325..327; /note=Cell attachment site; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 121,780 |
| Kinetics | |
| Metal Binding | METAL 231; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 235; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 241; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.19; |