| IED ID | IndEnz0002012482 |
| Enzyme Type ID | protease012482 |
| Protein Name |
Dorsal-ventral patterning tolloid-like protein 1 EC 3.4.24.- Mini fin protein |
| Gene Name | tll1 mfn tld tolloid |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MDYLYSALTSKMNWIALLLAGLTFCCKVSVHSCLDYDDSYDYYEEEKTETIDYKDPCKAAVFWGDIALDDEDLKMFHIDGTIDLKQQTHGRQGHTSGGLGEHVPTKKRGSLYLLLDRIRRLGFESWPVNSSKDVSSIKTGIRRVNSARNVKSRVPRAATSRAEKIWPGGVIPYVIGGNFTGSQRAMLKQAMRHWEKQTCVTFIEKTDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDVNSLGEPYDFDSIMHYARNTFSRGMFLDTILPSRDENGVRPAIGQRTRLSKGDISQAKKLYRCPACGETLQDSVGNFSSPGYPNGYPSYTHCVWRISVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKAPLLGRFCGDKIPEVLVSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEISKDSGQIQSPNYPDDYRPSKECVWRITVSEGYSVGLSFQVFEIERHDSCAYDYLEVRDGLSENSPLIGRFCGYDKPEDIRSTSNNLWMKFVSDGTVNKAGFAANFFKEEDECLKPDNGGCEQRCVNTLGSFKCACDPGYELAPDKKSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISMQFEAFELEGNEVCKYDYVEVRSGLSSDSKLHGKYCGTEVPEVITSQYNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECINTIGSYVCQCRNGFILHENKHDCKEAECEHKIHSTTGTISSPNWPDKYPSRKECTWDITATPGHRVKISFNEFEIEQHQECAYDHLEAFDGDSDKTPILSRLCGNKIPEPLISTGNKMYLRFISDASVQRKGFQATHSTECGGRLKAEARQKNLYSHAQFGDNNYPGHTDCEWLIVAESGYGIELTFTTFEVEEEADCGYDYIELYDGYDTGAHKIGRFCGSGPREELYSAGDAVLIHFHSDDTISKKGFHIRYTSTKFQEALHTRK |
| Enzyme Length | 1022 |
| Uniprot Accession Number | O57460 |
| Absorption | |
| Active Site | ACT_SITE 250; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. {ECO:0000269|PubMed:10375503, ECO:0000269|PubMed:9395394}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (19); Domain (8); Glycosylation (5); Metal binding (3); Propeptide (1); Signal peptide (1) |
| Keywords | Calcium;Developmental protein;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..32; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11477706; 11969259; 15525664; 16518392; 16530746; 16824737; 20886103; 21610036; 9007231; 9007245; |
| Motif | |
| Gene Encoded By | |
| Mass | 115,536 |
| Kinetics | |
| Metal Binding | METAL 249; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 253; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 259; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |