| IED ID |
IndEnz0002012503 |
| Enzyme Type ID |
protease012503 |
| Protein Name |
Tetraspanin-14
|
| Gene Name |
tsp-14 F39C12.3 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MPHRAPRRFMKTAPGACDWEQCLLMGSGEPTRARAVVSSSHKQRKPRQEISACLKWLVFLLNSIVFLVGVGILALGVYLFIKDFREVKLVDIILNPAILISIFGFSICVVSFFGFMGALRDNIFLLKCFAACVFLSYILVVAVTLVFFTLFYTDTTEGLSANWLLLYAVKNYHTNRNLAEIMDALQENLECCGVSSIAQGYRDWNMSYQFNCTNSNPQPEKCGVPFSCCRKSVISEAAGSSNPLLPAMRSLECWQNALTKRPGDLEHDIYTRGCLQPLRTLFESHAVHVGAFVALLIVPVCISVCLTNILAKQVDHQRYLLEREARRNDRRRKRDHNRRDQLNSLDLLEEGKFNNASANATRPRPPDIPPPLPPIEHVPRKKSRNASSSPTRKPKSAGVENAAARRKRTATTTRTPPAAAGPAPTPQATTTNRTHQWVLQQTDLVPQKSKS |
| Enzyme Length |
451 |
| Uniprot Accession Number |
H2L006 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Together with tsp-12, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling (PubMed:25978409, PubMed:28068334). Together with tsp-12, probably acts by modulating the activation of glp-1, Notch-like receptor, to regulate germline maturation (PubMed:20220101). {ECO:0000269|PubMed:20220101, ECO:0000269|PubMed:25978409, ECO:0000269|PubMed:28068334}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (1); Chain (1); Compositional bias (2); Glycosylation (2); Region (1); Topological domain (5); Transmembrane (4) |
| Keywords |
Alternative splicing;Cell membrane;Glycoprotein;Membrane;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU361218}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10778742;
12097347;
17267812;
21177967;
22267497;
22286215;
22560298;
23800452;
24884423;
25487147;
31988138;
6593563;
|
| Motif |
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| Gene Encoded By |
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| Mass |
50,451 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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