| IED ID | IndEnz0002012504 |
| Enzyme Type ID | protease012504 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 7 EC 3.4.19.12 Deubiquitinating enzyme 7 Ubiquitin thioesterase 7 Ubiquitin-specific-processing protease 7 |
| Gene Name | math-33 CBG23105 |
| Organism | Caenorhabditis briggsae |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
| Enzyme Sequence | MCSPDPEDMHILTNDIPSFDKSLDPYGPEGHLALDIERFSSFMNKPDSRIMSKPVIVRGIPWRILAICRHQQNNRQVATSRSRNNYNFGFFLQCNNDDLLQKRGMWRCYGQATLEVLNANGPPIQKKIHHSFHNTEVDWGFSNYDQYDTLTSPKDGYVIDDVIRLRCRFTADVPTGANYMWDSKKHTGCIGLRNQGATCYMNSILQSFYFTTGFRRAVYNMEVGTEPNESNIVLAMQRVFYELQMSSEAVETNSLTRAFGWDKLDAFNQHDVQEFCRVLLDNLETKMKGTSEEKSIPNLFRGNMKSYIKCLDVDYESSRTESFYDVQLNVLGMDSLERAFDAYTTPETLDDDNKYDAGDHGLQRAEKGVKFVELPPVLHVQLMRFQYCGVEQKINERFSFPEKMNLSNCCELGPMLNEEDCVYSLHAVLVHSGEFHGGHYVTYINVNLHESAVDPTATAKWCKFDDDVVSRTTTDDAIVSNFGGEKAMNSSAYMLVYVRDNAIDQVLAPIPDTQIPQSVSRTFEMERMHRNREKKKQEEEQMCMSITLVTPDILATNHSFDLIEPVTITDVLPHETVYKHMVTAELYQFVQEKLFEKSTLPKVDMFDSDDETRMKRKEILRRLKTKKFGFRLWRMTDSYTVDKPQKMASRLRPSDFIEYSIDTRLDHTLSHDTETIYVEHSQFLQPLNEYLPTRDILFFLKYYDAITDKFTIIGHVTLDSHKRLNLYRMTFCDLLGLPKDTELKYYIEHAPNHVEQIDDPNRSTISRLVDDQDGAIVIVEKADPTAKKDAKTKMIELYNDVEFEFSQQFYSKMPNEEPFELFTKRFCLEQKLTDVTEFIGSELNVDPRNVMLWTRVSGSRFEPNFDDYAVTGIQCKYLTLRTLHDPRQHKKYSVSYAIFPFPVNEVHTTRMFVRLYRQMPNGNVEELNLFPPKDGTVTDLIAEAKRYYPSVEGGSGKFRLLQIGTSPLNNQRVFQIYNENTAIVDLDQRPVYKQQAQHTLNCRIEEIPHDELDVAQGEFFCPVVHYDREPTKLFGVSFVIKIRNGELMTDVRDRLRRKLPDVSDAEFAKYKFALLSRDKLCRNIEFNAGEKVNLMDMANQTTGVPQVYIGLDHKSPSQHSNEAAIRILN |
| Enzyme Length | 1129 |
| Uniprot Accession Number | Q60MK8 |
| Absorption | |
| Active Site | ACT_SITE 199; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 439; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q93009}; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Hydrolase that deubiquitinates target proteins. {ECO:0000250|UniProtKB:Q93009}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (2) |
| Keywords | Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q93009}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 130,838 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |