| IED ID | IndEnz0002012615 |
| Enzyme Type ID | protease012615 |
| Protein Name |
Protein Z-dependent protease inhibitor PZ-dependent protease inhibitor PZI Serpin A10 |
| Gene Name | SERPINA10 ZPI UNQ707/PRO1358 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPTLL |
| Enzyme Length | 444 |
| Uniprot Accession Number | Q9UK55 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. {ECO:0000269|PubMed:11049983}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (19); Chain (1); Erroneous initiation (1); Glycosylation (4); Helix (13); Modified residue (1); Mutagenesis (1); Natural variant (10); Region (2); Signal peptide (1); Site (3); Turn (4) |
| Keywords | 3D-structure;Blood coagulation;Direct protein sequencing;Glycoprotein;Hemostasis;Heparin-binding;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | P00742; P22891 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 56; /note=Phosphoserine; by FAM20C; /evidence=ECO:0000269|PubMed:26091039 |
| Post Translational Modification | PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000269|PubMed:9689066 |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 3F1S; 3H5C; 4AFX; 4AJU; |
| Mapped Pubmed ID | 16079143; 16093243; 16527896; 17582153; 18710385; 18768472; 19172319; 19913121; 20024489; 20458435; 20628086; 21220417; 21975032; 21988832; 22039093; 22274138; 22399118; 22424030; 22786881; 23269381; 23530052; 24158387; 24315319; 24960590; 26982741; 28717005; 29302946; 30918026; 33427552; |
| Motif | |
| Gene Encoded By | |
| Mass | 50,707 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |