| IED ID | IndEnz0002012623 |
| Enzyme Type ID | protease012623 |
| Protein Name |
WAP four-disulfide core domain protein 2 Epididymal secretory protein E4 Major epididymis-specific protein E4 Putative protease inhibitor WAP5 |
| Gene Name | WFDC2 HE4 WAP5 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MPACRLGPLAAALLLSLLLFGFTLVSGTGAEKTGVCPELQADQNCTQECVSDSECADNLKCCSAGCATFCSLPNDKEGSCPQVNINFPQLGLCRDQCQVDSQCPGQMKCCRNGCGKVSCVTPNF |
| Enzyme Length | 124 |
| Uniprot Accession Number | Q14508 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Broad range protease inhibitor. {ECO:0000269|PubMed:23139753}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (7); Chain (1); Disulfide bond (8); Domain (2); Glycosylation (1); Sequence conflict (3); Signal peptide (1) |
| Keywords | Alternative splicing;Aspartic protease inhibitor;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal;Thiol protease inhibitor |
| Interact With | P07355; Q3SXY8; P11912; O75208; Q7Z7G2; Q96BA8; P00387; Q5JX71; Q9Y680; Q5T7V8; Q96RD7; A1A5C7-2; P27105; Q9Y320 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15781627, ECO:0000269|PubMed:23139753}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..30; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16169070; 20171287; 20360068; |
| Motif | |
| Gene Encoded By | |
| Mass | 12,993 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |