| IED ID | IndEnz0002012631 |
| Enzyme Type ID | protease012631 |
| Protein Name |
Zinc metalloproteinase-disintegrin-like TSV-DM EC 3.4.24.- Snake venom metalloproteinase SVMP |
| Gene Name | |
| Organism | Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Trimeresurus Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri) |
| Enzyme Sequence | MIQVLLVTICLAVFPYQGSSIILESGNVNDYEVVYPRKVTSLPKGAVQQKYEDAMQYELKVNGEPVVLHLEKNKGLFSKDYSETHYSPDGRKITTKPPVKDHCYYHGHIQNDADSTASISACNGLKGHFKLQGEMYLIEPLKLPDSEAHAVFKYENVEKEDEAPKMCGVTETNWESDEPIKEASQSNLTPEQQSYLNAPKYVKFFLVADHIMYLKYGRNLTTLRTRIFDTVNVVYLILLRINIHVLLVGMEIWSHKDKIIVQSVPAVTLKLFATWREADLLKHKSHGCAHLLTGINFNGPTAGLAYLGAICNPMYSAGIVQDHNKIHHLVAIAMAHELGHNLGINHDKDTCTCRAKACVMAGTISCDASYLFSDCSRQEHREFLIKNMPQCILKKPLKTDVVSPPVCGNYFVEVGEDCDCGSPATCRDSCCNPTNCKLRQGAQCAEGLCCDQCRFKGAGTECRPASSECDMADLCTGRSAECTDRFQRNGQPCQNNNGYCYNGTCPSMTDQCIALFGPNAAVSQDACFQFNREGNHYGYCRKEQNTKIACEPENVKCGRLYCIDSSPANKNPCNIVYLPNDEEKGMVLAGTKCADGRACNSNGQCVGVNGAYKSTTGFSQI |
| Enzyme Length | 621 |
| Uniprot Accession Number | Q2LD49 |
| Absorption | |
| Active Site | ACT_SITE 337; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by EDTA and DTT, and partially inhibited by EGTA, but not inhibited by PMSF and NEM. {ECO:0000269|PubMed:16487560}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom zinc metalloprotease that hydrolyzes the alpha-chain (FGA) and more slowly the beta-chain (FGB) of fibrinogen. Inhibits cell proliferation and induces cell morphologic changes transiently on human umbilical vein endothelial cells. {ECO:0000269|PubMed:16487560}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (18); Domain (2); Glycosylation (2); Metal binding (14); Modified residue (1); Motif (1); Propeptide (1); Signal peptide (1) |
| Keywords | Calcium;Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Pyrrolidone carboxylic acid;Secreted;Signal;Toxin;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 192; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000305|PubMed:16487560 |
| Post Translational Modification | PTM: The N-terminus is blocked. {ECO:0000269|PubMed:16487560}. |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 468..470; /note=D/ECD-tripeptide |
| Gene Encoded By | |
| Mass | 68,718 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25.0 uM for NFF-2 (fluorogenic substrates with cleavage at Ala-Nva) {ECO:0000269|PubMed:18554518}; |
| Metal Binding | METAL 336; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 340; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 346; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 406; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250; METAL 409; /note=Calcium 1; /evidence=ECO:0000250; METAL 411; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250; METAL 413; /note=Calcium 1; /evidence=ECO:0000250; METAL 416; /note=Calcium 1; /evidence=ECO:0000250; METAL 419; /note=Calcium 1; /evidence=ECO:0000250; METAL 470; /note=Calcium 2; /evidence=ECO:0000250; METAL 471; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250; METAL 473; /note=Calcium 2; /evidence=ECO:0000250; METAL 484; /note=Calcium 2; /evidence=ECO:0000250; METAL 485; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |