| IED ID | IndEnz0002012707 |
| Enzyme Type ID | protease012707 |
| Protein Name |
Lon protease EC 3.4.21.53 ATP-dependent protease La |
| Gene Name | lon MSC_0454 |
| Organism | Mycoplasma mycoides subsp. mycoides SC (strain PG1) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Tenericutes Mollicutes Mycoplasmatales Mycoplasmataceae Mycoplasma Mycoplasma mycoides group Mycoplasma mycoides Mycoplasma mycoides subsp. mycoides Mycoplasma mycoides subsp. mycoides SC Mycoplasma mycoides subsp. mycoides SC (strain PG1) |
| Enzyme Sequence | MLQYLKKIKGVSFMKTIKLPVVVTRGIFILPSTSKTIEFGRVKSKNALDASADLYNNQIVVVSQESPLEEEPNLEHLFYLGTVADLSVKKVWKDGTISVELNYNQKIKIDEFVEEDNIIYAIGSVFEDKLPKTDAQKTKIKEALEELQEKHSFNTSELLLVFNENDFNKLNSLIYQIIDKMPLVSLNTKLLLIQSTSILEKLELLKELIINRPKSTIKLNNNLNNNSTVDSEINKKLKDKMDKQQKEYYLREKMRIIKEELDDENSDASQLDKYKKRLEEEPFPESVKEKILSSIKRIETMQPGSAEVNVERNYVDWMMSIPWWEQSEDIDDLKYAQEILEKHHFGLKKVKERIIEYLAVKQKTKSLKGPIITFVGPPGVGKTSLARSIAEALGKKFVKVSLGGVKDESEIRGHRKTYVGSMPGRIIQALKRAKVKNPLFLLDEIDKMASDNRGDPASAMLEVLDPEQNKEFSDHYIEEPYDLSTVMFIATANYIENIPEALYDRMEIINLSSYTEIEKMHIAKDYLTKKILEEDQLTEDELRFTDEAYDEIIKYYTREAGVRQLERHLATIARKFIVKLLNGEITNLVVTREVVVQYLGKHIFEHTSKEEESQVGVVTGLAYTQFGGDILPIEVSTYNGKGNLTLTGKLGEVMKESATIALTYVKANHEKFGISKDKFDDIDIHIHVPEGAVPKDGPSAGITLTTALISALSKQPVSKDFGMTGEITLRGNVLPIGGLREKSISAARSGLKHILIPSKNVKDIEDVPQEVQDVLKITPVSKYEDVYEIIFKNNNQ |
| Enzyme Length | 796 |
| Uniprot Accession Number | Q6MTF4 |
| Absorption | |
| Active Site | ACT_SITE 699; /evidence=ECO:0000255|HAMAP-Rule:MF_01973; ACT_SITE 742; /evidence=ECO:0000255|HAMAP-Rule:MF_01973 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_01973}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. {ECO:0000255|HAMAP-Rule:MF_01973}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 376..383; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_01973 |
| Features | Active site (2); Chain (1); Domain (2); Nucleotide binding (1) |
| Keywords | ATP-binding;Cytoplasm;Hydrolase;Nucleotide-binding;Protease;Reference proteome;Serine protease;Stress response |
| Interact With | |
| Induction | INDUCTION: By heat shock. {ECO:0000255|HAMAP-Rule:MF_01973}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01973}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 90,443 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |