| IED ID | IndEnz0002012724 |
| Enzyme Type ID | protease012724 |
| Protein Name |
Pro-apoptotic serine protease nma111 EC 3.4.21.- |
| Gene Name | nma111 AFUA_6G13650 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MDLNGETSTKRKRSSVAAPAERPAKHLKPGNSTLTPGDATPANGTVYNVEDEEDTGRVMPIGPAQADSPEWQATIEKVVKSVVSIHFCQTCSFDTDLSMSSQATGFVVDAERGYILTNRHVVCAGPFWGYCIFDNHEECDVHPVYRDPVHDFGILKFNPKAIRYMELTELKLRPEAARVGCEIRVVGNDAGEKLSILSGVISRLDRNAPEYGDGYCDFNTNYIQAAAAASGGSSGSPVVNIDGHAIALQAGGRADGAATDYFLPLDRPLRALECIRRGEPVTRGTIQTQWILKPFDECRRLGLTPEWEAAVRKASPHETSMLVAEIILPEGPADGKLEEGDVLLQVNGELLTQFIRLDDILDSSVGKTVRLLVQRGGQNVEVECEVGDLHAITPDRFVTVAGGTFHNLSYQQARLYAIAARGVYVCEAAGSFKLENTLSGWIIDAVDKRPTRNLDEFIEVMKTIPDRARVVISYRHIRDLHTRGTSIVYIDRHWHPKMRMAIRNDETGLWDFSDLADPVPAETPVPRKADFIQLDGVSQPAVADIVRSFVRVSCTMPLKLDGYPQAKKTGFGLVIDAGKGLVVVSRAIVPYDLCDINITVADSIIVVAKVIFMHPLQNYTIIQYDPSLVQAPVQSAELSTEYIKQGQETIFVGFNQNFRIVVAKTAVTDITTVSIPANASAPRYRAINLDAITVDTGLSGQCTNGVLIGEDGVVQALWLNYLGERTPNSHKDVEYHLGFATPALLPVTSKIQQGIIPKLRILNMESYVVQMSQARIMGVSEEWIQKVAQANPSRHQLFMVRKVDCPPPQFTSNADSLQEGDIILTLDGQLITRVSELDKMYEKEVLDALIVRNGQEIHLKLPTVPTEDLETDRAVVFCGAVLQKPHHAVRQQISKLHSEVYVSARSRGSPAYQYGLAPTNFITAVNGVSTPNLDSFVREVSMIPDNTYFRLRAVTFDNVPWVVTMKKNDHYFPMSEYVKDPSQPLGWRTVSHERDRHKDGITPDAANLNPDAMDEVYEEVSDVEPEVD |
| Enzyme Length | 1028 |
| Uniprot Accession Number | Q4WLG1 |
| Absorption | |
| Active Site | ACT_SITE 120; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 151; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 233; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Nuclear serine protease which mediates apoptosis. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Domain (2); Region (3) |
| Keywords | Apoptosis;Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 113,599 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |