| IED ID | IndEnz0002012822 |
| Enzyme Type ID | protease012822 |
| Protein Name |
Trypsin EC 3.4.21.4 Fragment |
| Gene Name | |
| Organism | Simulium vittatum (Striped black fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Chironomoidea Simuliidae (black flies) Simuliinae Simuliini Simulium Psilozia Simulium vittatum (Striped black fly) |
| Enzyme Sequence | LTTVISYFALVAFALVGVSYATPKASINGRIVGGEMTDISLIPYQVSVQTAISSYGFIHHCGGSIISPRWVVTAAHCAQKTNSAYQVYTGSSNKVEGGQAYRVKTIINHPLYDEETTDYDVALLELAEPIVMNYKTAAIELAEVGEEVETDAMAIVSGWGDTKNFGEEPNMLRSAEVPIFDQELCAYLNANHGVVTERMICAGYLAGGRDSCQGDSGGPLAVDGKLVGIVSWGVGCAQSNFPGVYGI |
| Enzyme Length | 247 |
| Uniprot Accession Number | P35048 |
| Absorption | |
| Active Site | ACT_SITE 76; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 120; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; |
| DNA Binding | |
| EC Number | 3.4.21.4 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Domain (1); Non-terminal residue (2); Propeptide (1); Signal peptide (1); Site (1) |
| Keywords | Disulfide bond;Hydrolase;Protease;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL <1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 26,247 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |