| IED ID | IndEnz0002012878 |
| Enzyme Type ID | protease012878 |
| Protein Name |
Thermopsin EC 3.4.23.42 |
| Gene Name | thpS Saci_1714 |
| Organism | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
| Taxonomic Lineage | cellular organisms Archaea TACK group Crenarchaeota Thermoprotei Sulfolobales Sulfolobaceae Sulfolobus Sulfolobus acidocaldarius Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
| Enzyme Sequence | MNFKSICLIILLSALIIPYIPQNIYFFPHRNTTGATISSGLYVNPYLYYTSPPAPAGIASFGLYNYSGNVTPYVITTNEMLGYVNITSLLAYNREALRYGVDPYSATLQFNIVLSVNTSNGVYAYWLQDVGQFQTNKNSLTFIDNVWNLTGSLSTLSSSAITGNGQVASAGGGQTFYYDVGPSYTYSFPLSYIYIINMSYTSNAVYVWIGYEIIQIGQTEYGTVNYYDKITIYQPNIISASLMINGNNYTPNGLYYDAELVWGGGGNGAPTSFNSLNCTLGLYYISNGSITPVPSLYTFGADTAEAAYNVYTTMNNGVPIAYNGIENLTILTNNFSVILI |
| Enzyme Length | 340 |
| Uniprot Accession Number | P17118 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specificity similar to pepsin A, prefers bulky hydrophobic side-chains on either side of the scissible bond.; EC=3.4.23.42; |
| DNA Binding | |
| EC Number | 3.4.23.42 |
| Enzyme Function | FUNCTION: May represent a new class of acid proteases. It digests proteins and peptides in acidic solution. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 90 degrees Celsius. Thermostable.; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 2.; |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous initiation (1); Glycosylation (10); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Direct protein sequencing;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. Note=May be linked to cells by covalent linkages through some side chains. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..28; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 37,262 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.23.42; |