| IED ID | IndEnz0002012887 |
| Enzyme Type ID | protease012887 |
| Protein Name |
Mast cell tryptase EC 3.4.21.59 |
| Gene Name | |
| Organism | Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Gerbillinae (gerbils) Meriones (jirds) Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) |
| Enzyme Sequence | MLKLLLLALPLFSLMHRSPLCQEWGIVGGQEAPGNKWPWQVSLRANETYWRHFCGGSLIHPQWVLTAAHCVGPTIADPNKVRVQLRKQYLYYHDHLLAVSRIITHPTFYATQNGADIALLELKNPVNISSHVHPVSLPPASETFPSGTLCWVTGWGNIDNDVSLPPPFPLKEVQVPVVENQLCDLKYHKGVYTGDNIHIVRDDMLCAGNEGHDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCALPNRPGIYTRVTYYLDWIHRYVPKDF |
| Enzyme Length | 270 |
| Uniprot Accession Number | P50342 |
| Absorption | |
| Active Site | ACT_SITE 69; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 116; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 219; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.; EC=3.4.21.59; |
| DNA Binding | |
| EC Number | 3.4.21.59 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (3); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 30,167 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.59; |