| IED ID | IndEnz0002012955 |
| Enzyme Type ID | protease012955 |
| Protein Name |
WAP four-disulfide core domain protein 5 Putative protease inhibitor WAP1 p53-responsive gene 5 protein |
| Gene Name | WFDC5 PRG5 WAP1 UNQ3036/PRO9842 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MRTQSLLLLGALLAVGSQLPAVFGRKKGEKSGGCPPDDGPCLLSVPDQCVEDSQCPLTRKCCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKKRCCHSACGRDCRDPARGTAPGCPGQANSDLGSVALHLSWGPTERVHDGRPGALPAGQHYLYQRWFQPSDNHWPADTSLQPIHPWFLLLGVKVHSLSSEEGLCITPVLCTTAIRASHPS |
| Enzyme Length | 224 |
| Uniprot Accession Number | Q8TCV5 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Putative acid-stable proteinase inhibitor. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Disulfide bond (8); Domain (2); Natural variant (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Alternative splicing;Disulfide bond;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With | Q12797-6; Q8WUW1; P27658; Q2WGJ6; Q6FHY5; O43765 |
| Induction | INDUCTION: By p53/TP53. {ECO:0000269|PubMed:10441517}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16462094; 17511965; |
| Motif | |
| Gene Encoded By | |
| Mass | 24,238 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |