| IED ID | IndEnz0002012957 |
| Enzyme Type ID | protease012957 |
| Protein Name |
Alpha-fibrinogenase A1 EC 3.4.21.- Snake venom serine protease SVSP Fragment |
| Gene Name | |
| Organism | Crotalus atrox (Western diamondback rattlesnake) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Crotalus Crotalus atrox (Western diamondback rattlesnake) |
| Enzyme Sequence | VIGGDECNINEHRSLVAIFDS |
| Enzyme Length | 21 |
| Uniprot Accession Number | Q9PRW4 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by PMSF, bovine aprotinin (APR), and soybean trypsin inhibitor (STI). Is not inhibited by EDTA, beta-mercaptoethanol, and high temperature (85 degrees Celsius). {ECO:0000269|PubMed:1616487, ECO:0000269|PubMed:8024586}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Snake venom serine protease that completely cleaves fibrinogen Aalpha chain (FGA), partially cleaves Bbeta chain (FGB) and has no activity on gamma chain. Is more potent that A2 and A3 alpha-fibrinogenases. Very active within 5 minutes. {ECO:0000269|PubMed:8024586}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Non-terminal residue (1); Sequence conflict (2) |
| Keywords | Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Hemostasis impairing toxin;Hydrolase;Protease;Secreted;Serine protease;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8024586}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,289 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |