| IED ID | IndEnz0002013052 |
| Enzyme Type ID | protease013052 |
| Protein Name |
Serine protease persephone EC 3.4.21.- |
| Gene Name | psh CG6367 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MPLKWSLLLGTFVLISCSSVEAAVTVGRACKVTDTMPGICRTSSDCEPLIDGYIKSGVLTLNDVPSCGLGAWGEIFCCPTKPCCDNSTITSVSTSSTTSTKAPMTSGRVDVPTFGSGDRPAVAACKKIRERKQQRSGNQLVIHIVGGYPVDPGVYPHMAAIGYITFGTDFRCGGSLIASRFVLTAAHCVNTDANTPAFVRLGAVNIENPDHSYQDIVIRSVKIHPQYVGNKYNDIAILELERDVVETDNIRPACLHTDATDPPSNSKFFVAGWGVLNVTTRARSKILLRAGLELVPLDQCNISYAEQPGSIRLLKQGVIDSLLCAIDQKLIADACKGDSGGPLIHELNVEDGMYTIMGVISSGFGCATVTPGLYTRVSSYLDFIEGIVWPDNRV |
| Enzyme Length | 394 |
| Uniprot Accession Number | Q9VWU1 |
| Absorption | |
| Active Site | ACT_SITE 187; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 234; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 339; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases (PubMed:12098703, PubMed:18724373, PubMed:16399077). Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz (PubMed:12098703, PubMed:18724373, PubMed:16399077). Nec regulates the cascade by inhibiting psh (PubMed:12098703). {ECO:0000269|PubMed:12098703, ECO:0000269|PubMed:16399077, ECO:0000269|PubMed:18724373}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (7); Domain (2); Glycosylation (3); Mutagenesis (2); Natural variant (3); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Immunity;Innate immunity;Protease;Reference proteome;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12098703}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12364793; 12568721; 14557290; 14603309; 14684822; 15032585; 15199954; 15199956; 15621536; 16360948; 16631589; 17190605; 17588928; 17996400; 18070343; 18854145; 19223926; 19381251; 19590012; 19740772; 19851448; 20089584; 20201042; 20220848; 20375079; 20551040; 21074052; 21209287; 21480662; 21540243; 21775770; 22227521; 22368770; 22518146; 22724070; 22824741; 23071443; 23401590; 23517918; 23632253; 23796791; 23868318; 23944235; 24120681; 24492611; 25043021; 25628309; 25901322; 26453810; 26843333; 27172210; 27282340; 27974438; 28250052; 28874153; 29091025; 29211760; 29268741; 29345010; 29452635; 29707694; 29804808; 30034391; 30131599; 30146479; 30367934; 31018123; 31068592; 31564469; 31722958; 32656090; 32774336; 32866212; 33358662; 33827210; 34569900; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,228 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |