| IED ID | IndEnz0002013066 |
| Enzyme Type ID | protease013066 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 16 EC 3.4.19.12 Deubiquitinating enzyme 16 Ubiquitin thioesterase 16 Ubiquitin-specific-processing protease 16 |
| Gene Name | UBP16 YPL072W LPF12W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MSWIKNVTESPTSLIKKVSCGLIIAASLYAIAPSLSALVFGDSKQSIGKYTTVGLINRGNDCFITSSLQGLAGIPRFVEYLKRIRTVLLELETKLSNNAKGDNPTVDNTTRHSRLENSSNSLAPLHESLTSLILDLISVKDRKTSISPKIVINTLESIFKSKISSKQNDAHEFTLILLQTLQEERSKLIDYSKQICNLNIPKFPFEGETSKFLVCLKCKGLSEPSYKQTFIRELSVPQQTSENLSNILAHDETEIIDDYSCLICQIRAILNHEEYRNFKDCTPDEILMLDRLKNYATKAPINENLPFEVEQYVKRYSKGNLQVSNIKGKVIKKDVVVQLPDILIVHLSRSTFNGITYSRNPCNVKFGERITLSEYTLAESGTITENRQVKYNLKSVVKHTGSHSSGHYMCYRRKTEIRFGKEDESSFRRAPVVNNEVNKNREQNVAHNDYKKSRYKKVKNALRYPYWQISDTAIKESTASTVLNEQKYAYMLYYERVNK |
| Enzyme Length | 499 |
| Uniprot Accession Number | Q02863 |
| Absorption | |
| Active Site | ACT_SITE 62; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 407; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11076031; 12914939; 16725216; 19489724; 20074044; 22479268; 22808334; 23208446; 26503781; 8982460; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,920 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |