| IED ID | IndEnz0002013100 |
| Enzyme Type ID | protease013100 |
| Protein Name |
Snake venom serine protease jerdonase SVSP EC 3.4.21.- Fragment |
| Gene Name | |
| Organism | Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Protobothrops Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii) |
| Enzyme Sequence | IIGGDECNINEHPFLVALYDA |
| Enzyme Length | 21 |
| Uniprot Accession Number | P0DMU0 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by PMSF and soybean trypsin inhibitor. Partially inhibited by L-cysteine and DTT. Not affected by EDTA. {ECO:0000269|PubMed:12897962}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Multifunctional venom serine protease that has fibrino(geno)lytic activity towards the A alpha-chain of human fibrinogen (FGA) and a slow activity towards the B beta-chain (FGB). Also hydrolyzes bovine low-molecular-mass kininogen and releases bradykinin. Catalyzes the hydrolysis of BAEE, S-2238 and S-2302. {ECO:0000269|PubMed:12897962}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Domain (1); Non-terminal residue (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Fibrinolytic toxin;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Protease;Secreted;Serine protease;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12897962}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated; contains 35.8% neutral carbohydrate. {ECO:0000269|PubMed:12897962}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,304 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.25 uM for S-2302 (plasma kallikrein substrate) {ECO:0000269|PubMed:12897962}; KM=41.6 uM for S-2238 (thrombin substrate) {ECO:0000269|PubMed:12897962}; |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |