| IED ID | IndEnz0002013150 |
| Enzyme Type ID | protease013150 |
| Protein Name |
Snake venom metalloproteinase Ac1 SVMP EC 3.4.24.- Ac1-proteinase |
| Gene Name | |
| Organism | Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Deinagkistrodon Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) |
| Enzyme Sequence | STEFQRYMEIVIVVDHSMVKKYNGDSPKIKAWVYEMINTITEGYRDLYIDIILSGLEIWSEKDLINVEASAGNTLKSFGEWRAKDLIHRISHDNAQLLTATDFDGPTIGLAYVASMCEPKLSVGVIQDHSSVNRLVAITLAHEMAHNLGVRHDEKDCVGVVYLCIMRIPVVEDKRSYFSDCSYIQCREYISKENPPCILNKP |
| Enzyme Length | 202 |
| Uniprot Accession Number | Q7LZS9 |
| Absorption | |
| Active Site | ACT_SITE 143; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Snake venom metalloproteinase that impairs hemostasis in the envenomed animal. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (2); Domain (1); Metal binding (7) |
| Keywords | Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 22,945 |
| Kinetics | |
| Metal Binding | METAL 9; /note=Calcium; /evidence=ECO:0000250; METAL 93; /note=Calcium; /evidence=ECO:0000250; METAL 142; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 146; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 152; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 197; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 200; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |