| IED ID | IndEnz0002013184 |
| Enzyme Type ID | protease013184 |
| Protein Name |
Tumor necrosis factor receptor superfamily member 10B Death receptor 5 MK CD antigen CD262 |
| Gene Name | Tnfrsf10b Dr5 Killer |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEPPGPSTPTASAAARADHYTPGLRPLPKRRLLYSFALLLAVLQAVFVPVTANPAHNRPAGLQRPEESPSRGPCLAGQYLSEGNCKPCREGIDYTSHSNHSLDSCILCTVCKEDKVVETRCNITTNTVCRCKPGTFEDKDSPEICQSCSNCTDGEEELTSCTPRENRKCVSKTAWASWHKLGLWIGLLVPVVLLIGALLVWKTGAWRQWLLCIKRGCERDPESANSVHSSLLDRQTSSTTNDSNHNTEPGKTQKTGKKLLVPVNGNDSADDLKFIFEYCSDIVPFDSWNRLMRQLGLTDNQIQMVKAETLVTREALYQMLLKWRHQTGRSASINHLLDALEAVEERDAMEKIEDYAVKSGRFTYQNAAAQPETGPGGSQCV |
| Enzyme Length | 381 |
| Uniprot Accession Number | Q9QZM4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. {ECO:0000250|UniProtKB:O14763}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Disulfide bond (7); Domain (1); Glycosylation (1); Region (1); Repeat (3); Sequence conflict (10); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Apoptosis;Disulfide bond;Glycoprotein;Membrane;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | INDUCTION: TNFRSF10B is regulated by the tumor suppressor p53. |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | PTM: (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:30902834}. |
| Signal Peptide | SIGNAL 1..52; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10862756; 11217851; 11239407; 12466851; 12819136; 14610273; 14769851; 15044455; 15128592; 15173180; 15514675; 15589175; 15713653; 16602821; 17026999; 17041756; 17051329; 17126290; 17617585; 18006832; 18079962; 18079967; 18192669; 18667695; 18776938; 18802095; 19226377; 19273598; 19349211; 20807702; 21040902; 21169546; 21225479; 21251615; 21677750; 21768400; 21832159; 21938487; 21941003; 22013112; 22789540; 22916132; 23071253; 23347256; 23430714; 23605004; 23676461; 23815209; 24117005; 24466325; 24695582; 24971483; 24994655; 25843002; 26383973; 26609054; 26791792; 26982364; 26991125; 28444885; 29403497; 29436413; 30254289; 30423122; 30635284; 30850660; 30858352; 30988397; 31473246; 33323382; 33875613; 34223817; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,165 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |