| IED ID | IndEnz0002013200 |
| Enzyme Type ID | protease013200 |
| Protein Name |
Venom prothrombin activator vPA Fragment |
| Gene Name | |
| Organism | Bothrops atrox (Barba amarilla) (Fer-de-lance) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Bothrops Bothrops atrox (Barba amarilla) (Fer-de-lance) |
| Enzyme Sequence | ALVLIAFAQVLQQCP |
| Enzyme Length | 15 |
| Uniprot Accession Number | B3A0N1 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by EDTA, but not by PMSF. Activity is not dependent on the presence of calcium ions, phospholipids or FXa inhibitor. {ECO:0000269|Ref.1}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Snake prothrombin activator that attacks the hemostatic system of prey. This protein is functionally similar to blood coagulation factor Xa (By similarity). Potent calcium-independent prothrombin activator, possesses high hemorrhagic activity along with metalloproteinase activity. Has considerably stronger activity than FXa. {ECO:0000250|UniProtKB:P82807, ECO:0000269|Ref.1}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Non-terminal residue (1) |
| Keywords | Blood coagulation cascade activating toxin;Direct protein sequencing;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Protease;Prothrombin activator;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|Ref.1}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,614 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |