| IED ID | IndEnz0002013241 |
| Enzyme Type ID | protease013241 |
| Protein Name |
Zinc metalloproteinase/disintegrin Cleaved into: Snake venom metalloproteinase SVMP EC 3.4.24.- ; Disintegrin-like salmosin-5 Fragment |
| Gene Name | |
| Organism | Gloydius brevicaudus (Korean slamosa snake) (Agkistrodon halys brevicaudus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Crotalinae (pit vipers) Gloydius Gloydius brevicaudus (Korean slamosa snake) (Agkistrodon halys brevicaudus) |
| Enzyme Sequence | NHNPECIVNEPLGTDIVSPPVCGNELLEVGEECDCGTPENCQNECCDAATCKLKSGSQCGHGDCCEQCKFSKSGTECRESMSECDPAEHCSGQCSECPADVFHKNGQPCLDNYGYCYNGNCPIMYHQCYALWGADVYEAEDSCFESNKKGNYYYGYCRKENGKKIPCAPEDVKCGRLYCKDNSPGQNGPC |
| Enzyme Length | 190 |
| Uniprot Accession Number | O93518 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: [Snake venom metalloproteinase]: Impairs hemostasis in the envenomed animal. {ECO:0000250}.; FUNCTION: [Disintegrin-like salmosin-5]: Inhibits platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3) (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (2); Disulfide bond (6); Domain (2); Metal binding (11); Motif (1); Non-terminal residue (2); Propeptide (1) |
| Keywords | Calcium;Cell adhesion impairing toxin;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Platelet aggregation inhibiting toxin;Protease;Secreted;Toxin;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 83..85; /note=D/ECD-tripeptide |
| Gene Encoded By | |
| Mass | 20,811 |
| Kinetics | |
| Metal Binding | METAL 21; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250; METAL 24; /note=Calcium 1; /evidence=ECO:0000250; METAL 26; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250; METAL 28; /note=Calcium 1; /evidence=ECO:0000250; METAL 31; /note=Calcium 1; /evidence=ECO:0000250; METAL 34; /note=Calcium 1; /evidence=ECO:0000250; METAL 85; /note=Calcium 2; /evidence=ECO:0000250; METAL 86; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250; METAL 88; /note=Calcium 2; /evidence=ECO:0000250; METAL 100; /note=Calcium 2; /evidence=ECO:0000250; METAL 101; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |