| IED ID | IndEnz0002013278 |
| Enzyme Type ID | protease013278 |
| Protein Name |
Ufm1-specific protease UfSP EC 3.4.22.- Odorant response abnormal protein 8 |
| Gene Name | odr-8 ufsp-2 CBG05410 |
| Organism | Caenorhabditis briggsae |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
| Enzyme Sequence | MSGSQTVSVIGYTKMAPQSPPATVNELWFIDTQAMFQNYANLRSFSKSNSTETQTTIGGVVFGRKARKQVIHVFFAYAEDLTESNLQFLESSLSSDIELVGNVNIDGQSTLIGNGTFTLQLSSKMLENKNTSEFLDQNVIFNNDHISMEGASCVSKVGFEWSLRAGREQEDVKSAAERLSMASFRFSYLNAEHELVIREHKPETAKQKYMDKFTKGALPYKDVIEFTAMQSLTRDTSNDTEDQKLVPTVKVTKDNKHFTRLVTIGEVVFPAYFGDSSFDLYKRAREALNRRANNTMMVTVNGIRSGRGVTTTTSATYLPPGWVSLLHLQLPSKWTENEKRNYRIRLHKLFNLPSSKPCLRLSQSLPLHSESVRLTNKKLIREPHLSISNYQPAGVVTAVKGPYNYHHYMQDGIDDSGWGCAYRSFQTIWSWFILNGYTDKPVPSHRDIQQALVNIGDKEQKFVGSRQWIGSTEISYVLNELLKLECRFIATNSGAEVVERARELARHFETSGTPVMIGGNMLAHTILGVDFNEMTGETKFLILDPHYTGSEDIKTITSKGWCAWKPASFWSADHFYNMVLAQPPTDSI |
| Enzyme Length | 588 |
| Uniprot Accession Number | Q61UA0 |
| Absorption | |
| Active Site | ACT_SITE 420; /evidence=ECO:0000250; ACT_SITE 544; /evidence=ECO:0000250; ACT_SITE 546; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins. Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels. {ECO:0000250|UniProtKB:Q94218, ECO:0000250|UniProtKB:Q9NUQ7}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Cytoplasm;Endoplasmic reticulum;Hydrolase;Membrane;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q94218}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q94218}. Cytoplasm {ECO:0000250|UniProtKB:Q94218}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q94218}. Note=Recruited to the endoplasmic reticulum upon interaction with odr-4. {ECO:0000250|UniProtKB:Q94218}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 66,332 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |