| IED ID | IndEnz0002013349 |
| Enzyme Type ID | protease013349 |
| Protein Name |
Zinc finger FYVE domain-containing protein 9 Mothers against decapentaplegic homolog-interacting protein Madh-interacting protein Novel serine protease NSP Receptor activation anchor hSARA Smad anchor for receptor activation |
| Gene Name | ZFYVE9 MADHIP SARA SMADIP |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESAVSNESQPQLKVFSLAHSAPLTTEEEDHCANGQDCNLNPEIATMWIDENAVAEDQLIKRNYSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDAFSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVISSQGTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSDCLVPNEVRADENEGYEHEETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGDSGGQCVGLADAGLDLKGTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLMKKNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDFPANSGNNTKNKNDILGKAKLGENSATNVCSPSLGNISNVDTNGEHLESYEAEISTRPCLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGAEVAQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVSHDPVKPVTTSPLPAETDICLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVSNLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQEHIHIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIV |
| Enzyme Length | 1425 |
| Uniprot Accession Number | O95405 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. {ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:9865696}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Beta strand (32); Chain (1); Compositional bias (3); Erroneous initiation (1); Frameshift (1); Helix (17); Metal binding (8); Modified residue (2); Mutagenesis (10); Natural variant (3); Region (3); Turn (3); Zinc finger (1) |
| Keywords | 3D-structure;Alternative splicing;Cytoplasm;Endosome;Membrane;Metal-binding;Phosphoprotein;Receptor;Reference proteome;Zinc;Zinc-finger |
| Interact With | Q9Y561; P62136; P36873; P08100; Q15796; P84022; Q13277 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane. |
| Modified Residue | MOD_RES 306; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 668; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:24275569 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 1DEV; 1MK2; 4BKW; 5MJY; |
| Mapped Pubmed ID | 11100470; 12809483; 14718519; 15231748; 15350224; 17693260; 18511908; 20195357; 21358634; 22321011; 23139211; 24366813; 25416956; 28602823; 8980228; 9311995; 9346966; 9679059; |
| Motif | |
| Gene Encoded By | |
| Mass | 156,403 |
| Kinetics | |
| Metal Binding | METAL 705; /note=Zinc 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 708; /note=Zinc 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 721; /note=Zinc 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 724; /note=Zinc 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 729; /note=Zinc 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 732; /note=Zinc 1; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 750; /note=Zinc 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091; METAL 753; /note=Zinc 2; /evidence=ECO:0000255|PROSITE-ProRule:PRU00091 |
| Rhea ID | |
| Cross Reference Brenda |